Cyclization Approaches to the Synthesis of Natural Products

  • Kathlyn A. Parker
Conference paper


The synthesis of complex molecules and the development of synthetic methodology are complementary processes; indeed the syntheses which prove most efficient and therefore attain a touch of elegance are those in which there is a particularly adept match of target structure and the key step or steps.


Benzene Amide Aldehyde Ketone Dimethyl 


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  1. 1(aa).
    Kocienski, P. J., Lythgoe, B., J. Chem. Soc., Perkin I, 1980, 1400Google Scholar
  2. 1.(ab)
    Lythgoe, B., Waterhouse, P., J. Chem. Soc., Perkin I, 1980, 1405Google Scholar
  3. 1.(ac)
    Harrison, R. G., Lythgoe, B., Wright, P. W., Tetrahedron Lett., 1973, 3649.Google Scholar
  4. 1.(b)
    Baggiolini, E. G., Iacobelli, J. A., Hennessy, B. M., and Uskokovic, M. P., J. Am. Chem. Soc., 1982, 104, 2945.CrossRefGoogle Scholar
  5. 2.
    A thorough product study by Roush on a similar system had been reported: W. Roush, J. Org. Chem., 1979, 44, 4008. Roush’s data have proven extremely useful in the analysis of our own system.CrossRefGoogle Scholar
  6. 3.
    The same tactic has been employed by Wilson in a very similar approach to the vitamins D. Wilson, S. R., Hague, M. S., J. Qrg. Chem., 1982. 47, 5413.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Kathlyn A. Parker
    • 1
  1. 1.Department of ChemistryBrown UniversityProvidenceUSA

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