Regulation of the β-Adrenergic Receptor-Adenylate Cyclase System in Cardiac Membranes

  • W. Krawietz
Conference paper


The idea that drugs react with receptors was initiated by Langley [47] and Paul Ehrlich [27]. In small concentrations, some drugs induce a biological effect, whereas other drugs with different structures cause a comparable effect only in much higher concentrations. Paul Ehrlich [28] introduced the hypothesis that drugs that are effective in small concentrations are bound to a specific membrane protein (receptor). He pronounced the well-known sentence: corpora non agent nisi fixata.


Adenylate Cyclase Cholera Toxin Guanine Nucleotide Adenylate Cyclase Activity Nicotinamide Adenine Dinucleotide 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • W. Krawietz
    • 1
  1. 1.Medizinische Klinik I, Zentralklinikum AugsburgLehrkrankenhaus der Ludwig-Maximilians-Universität MünchenAugsburgFederal Republic of Germany

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