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Central Nervous Noradrenergic and Adrenergic Systems and their Functions

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New Aspects in Hypertension Adrenoceptors

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Abstract

It is not unusual to hear or read that the therapeutic effects of beta-adrenoceptive blocking agents (BABAs) upon a variety of cardiovascular disorders - including hypertension - are satisfactorily explained by a preferentially, if not exclusively, peripheral locus of action of these drugs. In other words, one tends to assume that BABAs correct, for example, an abnormally elevated blood pressure by interfering with signal transmission at a variety of peripheral, post- and presynaptically located beta-adrenergic receptor sites. Van Zwieten and Timmermans [63], on the basis of their results obtained with atenolol and metoprolol, were ready to conclude that “a central mechanism (does not) underly the antihypertensive activity of beta-blockers.”

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  1. 4104, Oberwil/Basel, Switzerland

    W. P. Koella

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  1. Medizinische Poliklinik der Ludwig-Maximilians-Universität München, Pettenkoferstr. 8 a, 8000, München 2, Federal Republic of Germany

    Martin Middeke  & Heinrich Holzgreve  & 

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Koella, W.P. (1986). Central Nervous Noradrenergic and Adrenergic Systems and their Functions. In: Middeke, M., Holzgreve, H. (eds) New Aspects in Hypertension Adrenoceptors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71418-4_1

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  • DOI: https://doi.org/10.1007/978-3-642-71418-4_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71420-7

  • Online ISBN: 978-3-642-71418-4

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