Abstract
The precise mechanism of mineralocorticoid-induced hypertension is still unclear. However, it has been well established that the pressor effect of the mineralocorticoid hormones is mediated by sodium, since it has been shown that their pressor action can be prevented by sodium restriction [1, 2]. Further evidence that sodium and volume retention play an important role in the pathogenesis of mineralocorticoid hypertension comes from the observation of an increased exchangeable sodium [1, 3] and extracellular fluid volume [1, 4] in patients with primary aldosteronism. Thus, mineralocorticoid hypertension represents a sodium- and volume-dependent type of hypertension.
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© 1986 Springer-Verlag Berlin Heidelberg
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Distler, A., Thiede, HM., Harwig, S., Philipp, T. (1986). Studies on the Blood Pressure Increasing Mechanism of Mineralocorticoids. In: Krück, F., Thurau, K. (eds) Endocrine Regulation of Electrolyte Balance. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71405-4_6
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DOI: https://doi.org/10.1007/978-3-642-71405-4_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16837-9
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