Abstract
While grafting of neural tissue has long been used with great success in developmental neurobiology (1), transplantation of neural tissue has only recently regained interest as a potentially fruitful approach to study both clinical and basic neurobiological questions regarding the extremely limited regenerative capacity of the adult mammalian central nervous system after injury. In the last decade considerable progress has been achieved, largely using rodents, into (a) establishing experimental procedures for implanting donor tissue into either neonatal or adult hosts, (b) determining the optimal age of donor tissue to achieve the greatest degree of viability after implantation, (c) determining to what extent there is anatomical integration of host and donor tissue, (d) assessing the potential of implants to repair functional or behavioural deficits (2, 3, 4). In broad terms it is now established that donor tissue taken from almost any part of the foetal rat CNS can be successfully transplanted to either neonatal or adult host brain, where the donor tissue will survive indefinitely (more than one year) and to a substantial degree complete normal development and differentiation.
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© 1987 Springer-Verlag Berlin Heidelberg
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Lindsay, R.M., Raisman, G., Seeley, P.J. (1987). Neural Tissue Transplants: Studies Using Tissue Culture Manipulations, Cell Marking Techniques and a Plasma Clot Method to Follow Development of Grafted Neurons and Glia. In: Althaus, H.H., Seifert, W. (eds) Glial-Neuronal Communication in Development and Regeneration. NATO ASI Series, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71381-1_36
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DOI: https://doi.org/10.1007/978-3-642-71381-1_36
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