Abstract
By far the best-characterized factor affecting nerve growth is the nerve growth factor (NGF), identified in 1956 by Cohen and Levi-Montalcini (for review, see Thoenen and Barde 1980), and subsequently sequenced and cloned. The purified protein has three major effects on sympathetic and sensory neurons cultured at appropriate development stages: it is required for cell survival, and enhances neurite outgrowth and neurotransmitter synthesis.
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References
Bennett MR, Lai K, Nurcombe V (1980) Identification of embryonic motoneurons in vitro: their survival is dependent on skeletal muscle. Brain Res 190: 537–542
Brown MC, Holland RL (1979) A central role for denervated tissues in causing nerve sprouting. Nature 282: 724–726
Brown MC, Holland RL, Hopkins WG (1981) Motor nerve sprouting. Annu Rev Neurosci 4: 17–42
Calof AL, Reichardt LF (1984) Motoneurons purified by cell sorting respond to two distinct activities in myotube-conditioned medium. Dev Biol 106: 194–210
Dribin LB, Barrett JN (1982) Two components of conditioned medium increase neuritic outgrowth from rat spinal cord explants. J Neurosci Res 8: 271–280
Ebendal T, Olson L, Seiger A, Hedlund KO (1980) Nerve growth factors in the rat iris. Nature 286: 25–28
Giller EL, Neale JH, Bullock PN, Schrier BK, Nelson PG (1977) Choline acetyltransferase activity of spinal cord cell cultures increased by co-culture with muscle and by muscle-conditioned medium. J Cell Biol 74: 16–29
Gundersen RW, Park KHC (1984) The effects of conditioned media on spinal neuntes: substrate-associated changes in neurite direction and adherence. Dev Biol 104: 18–27
Gurney ME (1984) Suppression of terminal sprouting at the neuromuscular junction by immune sera. Nature 307: 546–548
Gurney ME, Apatoff B (1984) Activity of a muscle-derived growth factor for spinal neurons in vitro and in vivo. Soc Neurosci Abstr 10: 1051
Hamburger V (1958) Regression versus peripheral control of differentiation in motor hypoplasia. Am J Anat 102: 365–410
Henderson CE (1983) Roles for retrograde factors in synapse formation at the nerve-muscle junction. Prog Brain Res 58: 369–373
Henderson CE, Huchet M, Changeux JP (1981) Neurite outgrowth from embryonic spinal neurons is promoted by media conditioned by muscle cells. Proc Natl Acad Sci USA 78: 2625–2629
Henderson CE, Huchet M, Changeux JP (1983) Denervation increases a neurite-promoting activity in extracts of skeletal muscle. Nature 302: 609–611
Henderson CE, Huchet M, Changeux JP (1984) Neurite-promoting activities for embryonic spinal neurons and their developmental changes in the chick. Dev Biol 104: 336–347
Henderson CE, Benoit P, Huchet M, Guénet JL, Changeux JP (1986) Increase of neurite-promoting activity for spinal neurons in muscles of “paralysé” mice and tenotomised rats. Dev Brain Res 25: 65–70
Hendry IA (1976) Control in the development of the vertebrate sympathetic nervous system. Rev Neurosci 2: 149–194
Hill MA, Bennett MR (1983) Cholinergic growth factor from skeletal muscle elevated following denervation. Neurosci Lett 35: 31–35
Hollyday M, Hamburger V (1976) Reduction of the naturally occurring motor neuron loss by enlargement of the periphery. J Comp Neurol 170: 311–320
Korsching S, Thoenen H (1983) Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation. Proc Natl Acad Sci USA 80: 3513–3516
Lander AD, Fujii D, Gospadorowicz D, Reichardt LF (1982) Characterization of a factor that promotes neurite outgrowth: evidence linking activity to a heparan sulfate proteoglycan. J Cell Biol 94: 574–585
Levi-Montalcini R, Booker B (1960) Destruction of the sympathetic ganglia in mammals by an antiserum to the nerve-growth promoting factor. Proc Natl Acad Sci USA 42: 384–391
Lewis J, Chevallier A, Kieny M, Wolpert L (1981) Muscle nerve branches do not develop in chick wings devoid of muscle. J Embryol Exp Morphol 64: 211–232
Longo FM, Manthorpe M, Varon S (1982) Spinal cord neuronotrophic factors. I. Bioassay of schwannoma and other conditioned media. Dev Brain Res 3: 277–294
Nix WA (1982) The effect of low-frequency electrical stimulation on the denervated extensor digitorum longus muscle of the rabbit. Acta Neurol Scand 66: 521–528
Nix WA (1986) Maintenance of muscle integrity following denervation. In: Dimitrijevic M, Kakulas BA, Vrbová G (eds) Recent achievements in restorative neurology. vol 3. Karger, Basel (in press)
Pittman RH, Oppenheim RW (1978) Neuromuscular blockade increase motoneurone survival during normal cell death in the chick embryo. Nature 271: 364–366
Pollack ED, Muhlach WL, Liebig V (1981) Neurotropic influence of mesenchymal limb target tissue on spinal cord neurite growth in vitro. J Comp Neurol 177: 87–112
Shelton DL, Reichardt LF (1984) Expression of the ß-NGF gene correlates with the density of sympathetic innervation in effector organs. Proc Natl Acad Sci USA 81: 7951–7955
Slack JR, Pockett S (1982) Motor neurotrophic factor in denervated adult skeletal muscle. Brain Res 247: 138–140
Tanaka H, Obata K (1982) Survival and neurite outgrowth of chick embryo spinal cord cells in serum-free culture. Dev Brain Res 4: 313–321
Thoenen H, Barde Y-A (1980) Physiology of nerve growth factor. Physiol Rev 60: 1284–1335
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© 1986 Springer-Verlag Berlin Heidelberg
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Henderson, C.E. (1986). Factors Influencing Motor Nerve Growth. In: Nix, W.A., Vrbová, G. (eds) Electrical Stimulation and Neuromuscular Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71337-8_5
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DOI: https://doi.org/10.1007/978-3-642-71337-8_5
Publisher Name: Springer, Berlin, Heidelberg
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