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The Effect of Long-Term Electrical Stimulation on Capillary Supply and Metabolism in Fast Skeletal Muscle

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Electrical Stimulation and Neuromuscular Disorders

Abstract

Salmons and Vrbová (1969) showed that chronic stimulation of rabbit fast muscles at a frequency naturally occurring in nerves to slow muscles (10 Hz continuously) changed the contractile properties towards those characteristic of slow muscles. Subsequent series of experiments (Pette et al. 1973, 1975, 1976, see Pette and Vrbová, 1985) demonstrated the effect of such stimulation on the transformation of the metabolic pattern with an increase in the activity of oxidative and decrease in glycolytic enzymes. It has been known for a long time (Ranvier 1874) that muscles with a high aerobic metabolism have a much better capillary supply than muscles with high glycolytic metabolism. Romanul (1965) showed a higher number of capillaries surrounding fibres with a high activity of oxidative enzymes in one muscle, and Gray and Renkin (1978) found, using quantitative evaluation, twice as many capillaries in relation to fibres with a high activity of succinate dehydrogenase (SDH) than in those with a low SDH activity. Hudlická (1982) showed a very good relationship between the activity of citrate synthase — estimated in many different muscles by Bass et al. (1969) — and capillary density (CD), and Hoppeler et al. (1981) demonstrated significant correlations between the volume density of mitochondria and CD in twenty different muscles of various mammals. It was thus not surprising to find increased capillary supply in chronically stimulated muscles (Cotter et al. 1973).

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References

  • Aitman TJ, Hudlická O, Tyler KR (1979) Long-term effects of tetanic stimulation on blood flow, metabolism and performance of fast skeletal muscles. J Physiol 295: 36–37P

    Google Scholar 

  • Ariano MA, Armstrong RB, Edgerton VR (1973) Hind-limb muscle fibre populations of five mammals. J Histochem Cytochem 21: 51–55

    Article  PubMed  CAS  Google Scholar 

  • Bass A, Brdiczka D, Eyer P, Hofer S, Pette D (1969) Metabolic differentiation of distinct muscle types at the level of enzymatic organization. Eur J Biochemi 10: 198–206

    Article  CAS  Google Scholar 

  • Brånemark PI (1965) Capillary form and function. Bibl Anat 7: 9–28

    PubMed  Google Scholar 

  • Brooke MH, Kaiser KK (1969) Some comments on the histochemical characterization of muscle adenosine triphosphatase. J Histochem Cytochem 17: 431–432

    Article  PubMed  CAS  Google Scholar 

  • Brown MD, Cotter MA, Hudlická O, Vrbová G (1976) The effects of different patterns of muscle activity on capillary density, mechanical properties and structure of slow and fast rabbit muscles. Pflugers Arch 361: 241–250

    Article  PubMed  CAS  Google Scholar 

  • Cotter M, Hudlická O, Vrbová G (1973) Growth of capillaries during long-term activity in skeletal muscle. Bibl Anat 11: 395–398

    PubMed  CAS  Google Scholar 

  • Dawson J, Hudlická O, Tyler KR (1983) Measurement of flow velocities in capillaries supplying fast and slow muscle fibres at rest and during contractions in the rat. J Physiol 338: 7P

    Google Scholar 

  • Galbo H, Holst JJ, Christensen NJ (1979) The effect of different diets and of insulin on the hormonal response to prolonged exercise. Acta Physiol Scand 107: 19–32

    Article  PubMed  CAS  Google Scholar 

  • Gale JB, Nagle FY (1971) Changes in ATP and creatinphosphate storage in skeletal muscles of rats trained at 900 and 7600 feet. Nature 232: 342

    Article  PubMed  CAS  Google Scholar 

  • Gray SD, Renkin EM (1978) Microvascular supply in relation to fiber metabolic type in mixed skeletal muscles of rabbit. Microvasc Res 16: 406–425

    Article  PubMed  CAS  Google Scholar 

  • Hoppeler H, Mathieu O, Weibel ER, Krauer R, Lindstedt SL, Taylor CR (1981) Design of the mammalian respiratory system. VIII Capillaries in skeletal muscle. Respir Physiol 44: 129–150

    Article  PubMed  CAS  Google Scholar 

  • Hoppeler H, Hudlická O, Uhlmann E (1983) The relationship between capillary density, volume density of mitochondria and maximal blood flow in various cat muscles. J Physiol 342: 32P

    Google Scholar 

  • Houston ME, Farrance BW, Wight RI (1982) Metabolic effects of two frequencies of short-term surface electrical stimulation on human muscle. Can J Physiol Pharmacol 60: 727–731

    Article  PubMed  CAS  Google Scholar 

  • Hudlická O (1982) Growth of capillaries in skeletal and cardiac muscle. Circ Res 50: 451–461

    PubMed  Google Scholar 

  • Hudlická O (1985) Development and adaptability of microvasculature in skeletal muscle. J Exp Biol 115: 319–331

    Google Scholar 

  • Hudlická O, el Khelly F (1985) Metabolic factors involved in regulation of muscle blood flow. J Cardiovasc Pharmacol [Suppl] 3: 559–572

    Google Scholar 

  • Hudlická O, Schroeder W (1978) Factors involved in capillary growth in a normal adult skeletal muscle (abstract). Fed Proc 37: 314

    Google Scholar 

  • Hudlická O, Tyler KR (1984) The effect of long-term high-frequency stimulation on capillary density and fibre types in rabbit fast muscles. J Physiol 353: 435–445

    PubMed  Google Scholar 

  • Hudlická O, Brown M, Cotter M, Smith M, Vrbová G (1977) The effect of long-term stimulation of fast muscles on their blood flow, metabolism and ability to withstand fatigue. Pflugers Arch 369: 141–149

    Article  PubMed  Google Scholar 

  • Hudlická O, Dodd L, Renkin EM, Gray SD (1982a) Early changes in fiber profiles and capillary density in long-term stimulated muscles. Am J Physiol 243: H528–535

    PubMed  Google Scholar 

  • Hudlická O, Tyler KR, Srihari T, Heilig A, Pette D (1982b) The effect of different patterns of long-term stimulation on contractile properties and myosing light chains in rabbit fast muscles. Pflu-gers Arch 393: 164–170

    Article  Google Scholar 

  • Hudlická O, Aitman T, Heilig A, Leberer E, Tyler KR, Pette D (1984) Effects of different patterns of long-term stimulation on blood flow, fuel uptake and enzyme activities in rabbit fast skeletal muscles. Pflugers Arch 402: 306–311

    Article  PubMed  Google Scholar 

  • Kanabus EW, Hudlická O, Tyler KR (1980) Skeletal muscle PO2 after chronic tetanic stimulation. Microvasc Res 20: 113–114

    Google Scholar 

  • Mathieu O, Cruz-Orive L-M, Hoppeler H, Weibel ER (1983) Estimating length density and quantifying anisotrophy in skeletal muscle capillaries. J Microsc 131: 131–146

    Article  PubMed  CAS  Google Scholar 

  • Myrhage R, Hudlická O (1976) The microvascular bed and capillary surface area in rat extensor hallucis proprius muscle (EHP). Microvasc Res 11: 315–323

    Article  PubMed  CAS  Google Scholar 

  • Myrhage R, Hudlická O (1978) Capillary growth in chronically stimulated adult skeletal muscle as studied by intravital microscopy and histological methods in rabbits and rats. Microvasc Res 16: 73–90

    Article  PubMed  CAS  Google Scholar 

  • Pearse AGE (1968) Histochemistry-theoretical and applied, 3rd ed., vol 1. Churchill, London

    Google Scholar 

  • Pette D, Tyler KR (1983) Response of succinate dehydrogenase activity in fibres of rabbit tibialis anterior muscle to chronic nerve stimulation. J Physiol 338: 1–9

    PubMed  CAS  Google Scholar 

  • Pette D, Vrbová G (1985) Neural control of phenotype expression in mammalian muscle fiber. Muscle Nerve 8: 676–689

    Article  PubMed  CAS  Google Scholar 

  • Pette D, Smith ME, Staudte HW, Vrbová G (1973) Effect of long-term electrical stimulation on some contractile metabolic characteristics of fast rabbit muscles. Pflugers Arch 338: 257–272

    Article  PubMed  CAS  Google Scholar 

  • Pette D, Ramirez BU, Muller W, Simon R, Exner GU, Hildebrand R (1975) Influence of intermittent stimulation on contractile, histochemical and metabolic properties of fibre populations in fast and slow rabbit muscles. Pflugers Arch 361: 1–7

    Article  PubMed  CAS  Google Scholar 

  • Pette D, Muller W, Leisner E, Vrbová G (1976) Time dependent effects on contractile properties, fiber population, myosin light chains and enzymes of energy metabolism in intermittently and continuously stimulated fast-twitch muscles of the rabbit. Pflugers Arch 364: 103–112

    Article  PubMed  CAS  Google Scholar 

  • Ranvier L (1874) Note sur les vaisseaux sanguins et la circulation dans les muscles rouges. CR Soc Biol (Paris) 26: 28–31

    Google Scholar 

  • Romanul FCA (1965) Capillary supply and metabolism of muscle fibers. Arch Neurol 12: 497–509

    PubMed  CAS  Google Scholar 

  • Salmons S, Vrbová G (1969) The influence of activity on some contractile characteristics of mammalian fast and slow muscles. J Physiol 201: 535–549

    PubMed  CAS  Google Scholar 

  • Thoma R (1911) Über die Histomechanik des Gefäßsystems und die Pathogenese der Angiosklerose. Virchows Archiv [A] 204: 1–74

    Google Scholar 

  • Waxman AM (1981) Blood vessel growth as a problem in morphogenesis: a physical theory. Microvasc Res 22: 32–41

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Physiology, University of Birmingham, Birmingham, B15 2TJ, UK

    O. Hudlická

  2. Department of Physiology, Marischal College, University of Aberdeen, Scotland

    M. A. Cotter

  3. Department of Surgery, St. George’s Medical School, London, UK

    J. Cooper

Authors
  1. O. Hudlická
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  2. M. A. Cotter
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  3. J. Cooper
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Editor information

Editors and Affiliations

  1. Neurologische Klinik, Universitätskliniken, Langenbeckstr. 1, D-6500, Mainz, Germany

    W. A. Nix

  2. Department of Anatomy and Centre for Neuroscience, University College, Gower Street, WC1E 6BT, London, UK

    G. Vrbová

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© 1986 Springer-Verlag Berlin Heidelberg

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Hudlická, O., Cotter, M.A., Cooper, J. (1986). The Effect of Long-Term Electrical Stimulation on Capillary Supply and Metabolism in Fast Skeletal Muscle. In: Nix, W.A., Vrbová, G. (eds) Electrical Stimulation and Neuromuscular Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71337-8_3

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  • DOI: https://doi.org/10.1007/978-3-642-71337-8_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71339-2

  • Online ISBN: 978-3-642-71337-8

  • eBook Packages: Springer Book Archive

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