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Aldehyde Dehydrogenase in Mammalian Peroxisomes

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Peroxisomes in Biology and Medicine

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

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Abstract

Clofibrate treatment caused a 2-3-fold increase in rat liver aldehyde dehydrogenase activity. The induced enzyme has a high Km for acetaldehyde and was found to be located in mitochondrial peroxisomes and microsomes. Disruption of the purified peroxisomes by different treatments with subsequent centrifugation of subpe-roxisomal components in a sucrose density gradient indicates that aldehyde dehydrogenase is located in the peroxisomal membrane. Partial purification of clofibrate-induced aldehyde dehydrogenases from microsomes and peroxisomes was undertaken. The enzymes are active with several aliphatic and aromatic aldehydes less formaldehyde and glyceraldehyde. According to its basic kinetic properties peroxisomal aldehyde dehydrogenase seems to be similar to a clofibrate-induced microsomal enzyme. The functional role of both enzymes in the liver cells is discussed.

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Author information

Authors and Affiliations

  1. All-Union Research Center, Kropotkinsky per. 23, Moscow, 119034, USSR

    V. D. Antonenkov, S. V. Pirozhkov & L. F. Panchenko

Authors
  1. V. D. Antonenkov
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  2. S. V. Pirozhkov
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  3. L. F. Panchenko
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Editor information

Editors and Affiliations

  1. Department of Anatomy II. Division, University of Heidelberg, 6900, Heidelberg, Germany

    H. Dariush Fahimi

  2. Institute for Physiological Chemistry I, University of Düsseldorf, Moorenstr. 5, 4000, Düsseldorf, Germany

    Helmut Sies

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© 1987 Springer-Verlag Berlin Heidelberg

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Antonenkov, V.D., Pirozhkov, S.V., Panchenko, L.F. (1987). Aldehyde Dehydrogenase in Mammalian Peroxisomes. In: Fahimi, H.D., Sies, H. (eds) Peroxisomes in Biology and Medicine. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71325-5_24

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  • DOI: https://doi.org/10.1007/978-3-642-71325-5_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71327-9

  • Online ISBN: 978-3-642-71325-5

  • eBook Packages: Springer Book Archive

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