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Amino Acid Metabolism in Animal Peroxisomes

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Book cover Peroxisomes in Biology and Medicine

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

Mammalian liver peroxisomes contain only one kind of aminotransferase, alanine:glyoxylate aminotransferase 1 (AGT 1). Hepatic organelles containing AGT 1 and its substrate specificity vary among mammalian. AGT 1 is located in peroxisomes in human, monkey, rabbit and guinea-pig, in the mitochondria in dog and cat, and in both organelles in rat, mouse and hamster. Rodent AGT 1 catalyze the transamination between various L-amino acids and pyruvate or glyoxylate, while other mammalian AGT 1 have only AGT and serine:pyruvate aminotransferase activities. Immunological distances of AGT 1 in different organelles from different mammalian species suggest that the peroxisomal and mitochondrial AGT 1 were orthologous proteins, and were not formed by divergent evolution after gene duplication. AGT 1 is present as the holoenzyme in mammalian liver, while AGT is present as the apoenzyme in chicken and chick embryonic liver. Furthermore, some evidence that animal peroxisomes play a role in detoxication of glyoxylate is presented.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Kyushu Dental College, Kitakyushu, 803, Japan

    T. Noguchi

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  1. T. Noguchi
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Editor information

Editors and Affiliations

  1. Department of Anatomy II. Division, University of Heidelberg, 6900, Heidelberg, Germany

    H. Dariush Fahimi

  2. Institute for Physiological Chemistry I, University of Düsseldorf, Moorenstr. 5, 4000, Düsseldorf, Germany

    Helmut Sies

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© 1987 Springer-Verlag Berlin Heidelberg

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Noguchi, T. (1987). Amino Acid Metabolism in Animal Peroxisomes. In: Fahimi, H.D., Sies, H. (eds) Peroxisomes in Biology and Medicine. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71325-5_23

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  • DOI: https://doi.org/10.1007/978-3-642-71325-5_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71327-9

  • Online ISBN: 978-3-642-71325-5

  • eBook Packages: Springer Book Archive

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