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New Trends in Allergy II pp 16–24Cite as

Regulation of IgE by Lymphoid Cell-Derived Factors

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Abstract

Both experiments in rodents and experiments of nature in man suggest that isotypic regulation of the IgE response and its suppression represent a normal state of regulation. Accordingly, the abnormally elevated production of IgE to ubiquitous allergens, as observed in atopic people, might represent to some extent a breakdown of suppression and the expression of a state of partial immunodeficiency. Recent studies by several groups suggest that the isotypic regulation of IgE production is operated at several levels:

  1. a)

    a network of T/B cell interactions in which non IgE-binding factors are produced by T and B cells (D. H. Katz);

  2. b)

    IgE-binding molecules produced by T cells controlling the production/secretion of IgE by IgE-bearing B cells (several groups);

  3. c)

    glycosylation-regulating factors which influence the enhancing or suppressing activity of IgE binding factors (K. Ishizaka).

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Authors and Affiliations

  1. Institut für Klinische Immunologie, Inselspital, 3000, Bern, Switzerland

    A. L. de Weck, B. Stadler & J. Knutti-Müller

Authors
  1. A. L. de Weck
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  2. B. Stadler
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  3. J. Knutti-Müller
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Editor information

Editors and Affiliations

  1. Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, Frauenlobstraße 9–11, 8000, Munich, Federal Republic of Germany

    Johannes Ring (Head: Prof. Dr. Dr. hc. O. Braun-Falco) & Günter Burg (Head: Prof. Dr. Dr. hc. O. Braun-Falco) (Head: Prof. Dr. Dr. hc. O. Braun-Falco) &  (Head: Prof. Dr. Dr. hc. O. Braun-Falco)

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© 1986 Springer-Verlag Berlin Heidelberg

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de Weck, A.L., Stadler, B., Knutti-Müller, J. (1986). Regulation of IgE by Lymphoid Cell-Derived Factors. In: Ring, J., Burg, G. (eds) New Trends in Allergy II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71316-3_3

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  • DOI: https://doi.org/10.1007/978-3-642-71316-3_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71318-7

  • Online ISBN: 978-3-642-71316-3

  • eBook Packages: Springer Book Archive

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