Genetic Features of Major Geographical Isolates of Mus musculus
Laboratory mice have greatly contributed to the remarkable advances in immunogenetics and mammalian molecular genetics for the last decade. At present many different mouse strains, both classical and newly developed, are available for genetic studies. It is quite reasonable with the extensive development of research in this field, that one would like to know the natural origin of laboratory mice based on their genetic constitution. We have already revealed that the mitochondrial genome and most of the nuclear genomes of the present laboratory mice originated from an European subspecies Mus musculus domesticus (Yonekawa et al 1980, 1982; Moriwaki et al 1982, 1985). From mtDNA sequences, Ferris et al (1982) suggested “Common laboratory strains of inbred mice are descended from a single female”. From stand points of either immunogenetics, molecular genetics or evolutionary genetics, it should be desirable to increase further the genetic diversity of the laboratory mice. This could be achieved by utilizing other mouse subspecies. Schwarz and Schwarz (1943) taxonomically discriminated 15 subspecies of mice of Old World origin.
KeywordsLaboratory Mouse EcoRI Fragment Wild Mouse European Subspecies Common Laboratory Strain
Unable to display preview. Download preview PDF.
- Moriwaki K, Miyashita N, Yonekawa H (1985) Genetic survey of the origin of laboratory mice and its implication in genetic monitoring. In:Archibold J, Ditchfield J, Rowsell HC (eds) The contribution of laboratory animal science to the welfare of man and animals, Gustav Fischer Verlag, Stuttgart, p237Google Scholar
- Moriwaki K, Shiroishi T, Yonekawa H, Miyashita N, Sagai T (1982) Genetic status of Japanese wild mice and immunological characters of their H-2 antigens. In:Muramatsu T, Cachelin G, Moscona AA, Ikawa Y (eds) Teratocarcinoma and embryonic cell interactions, Japan Scientific Soc Press and Academic Press, Tokyo, pl57Google Scholar
- Sage RD (1981) Wild mice. In:Foster HL, Small JD, Fox JG (eds) The mouse in biomedical research, Vol. 1, Academic Press, New York, p39Google Scholar
- Suzuki H, Miyashita N, Moriwaki K, Kominami R, Muramatsu M, Kanehisa T, Bonhomme F, Petras ML, Yu ZC, Lu DY (to be published) Evolutionary implication of heterogeneity of the non-transcribed spacer region of ribosomal DNA repeating units in various subspecies of Mus musculus. Mol Biol EvolGoogle Scholar
- Yonekawa H, Moriwaki K, Gotoh O, Watanabe J, Hayashi JI, Miyashita N, Petras ML, Tagashira Y (1980) Relationship between laboratory mice and the subspecies of Mus musculus domesticus based on restriction endonuclease cleavage patterns of mitochondrial DNA. Jap J Genet 50:289–296CrossRefGoogle Scholar