Variable Resistance to Ectromelia (Mousepox) Virus Among Genera of Mus

  • R. M. L. Buller
  • M. Potter
  • G. D. Wallace
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 127)


Ectromelia virus, an orthopoxvirus, is a member of the poxvirus family. It replicates in the cytoplasm of infected cells producing progeny virions which are “brick-shaped” with dimensions of approximately 200 by 300 nm, and contain a double-stranded DNA genome of 130–140×l06 daltons MW. (Mackett and Archard 1979). The virus naturally infects M. m. domestieus in animal colonies causing a severe disease (mousepox) in certain strains (A/J, DBA/2J, BALB/cByJ), and a subclinical infection in others (AKR/J, C57BL/6J, C57BL) (Schell 1960; Wallace and Buller 1985). Much speculation has centered on the question of a potential wildlife host for ectromelia virus. Fenner examined 150 wild mice from the area of Melbourne, Australia without finding evidence for prior exposure to this virus (Fenner 1949). Kaplan et al. (1980) have presented serologic evidence suggesting that field mice (Apodemus) and voles (Microtus and Clethrionomys) can be infected with an orthopoxvirus, but no direct evidence that these species are natural reservoirs for ectromelia virus is available. Thus it was of interest to study closer relatives of M. m. domesticus for susceptibility to ectromelia virus.


Field Mouse Intraperitoneal Route Animal Coloni Ectromelia Virus Virus Neutralization Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Burnet FM, Lush D (1936) Inapparent (subclinical) infection of the rat with the virus of infectious ectromelia of mice. J Path Bacterol 43:469–476CrossRefGoogle Scholar
  2. Fenner F (1947) Studies in infectious ectromelia of mice. I. Immunization of mice against ectromelia with living vaccinia virus. Aust J Exp Biol Med Sci 25:257–274PubMedCrossRefGoogle Scholar
  3. Fenner F (1949) Mousepox (infectious ectromelia of mice): A review. J Immunol 63:341–373PubMedGoogle Scholar
  4. Kaplan C, Healing TD, Evans N, Healing L, Prin A (1980) Evidence of infection by viruses in small British field rodents. J Hyg 84:285–294.CrossRefGoogle Scholar
  5. Lennette EH, Schmidt NJ (1979) Diagnostic Procedures for viral, rickettsial and chlamydial infectious (American Public Health Association Inc. 1979) p 291Google Scholar
  6. Mackett M, Archard LC (1979) Conservation and variation in orthopoxvirus genome structure. J Gen Virol 45:683–701PubMedCrossRefGoogle Scholar
  7. Missone X (1969) African and Australia Murida Evolutionary Trends. Belgique Annales Serie in 80 Sciences Zoologiques No 172, 1–213Google Scholar
  8. Mooser IT (1943) Über die Mischinfektion der weissen Maus mit einem Stamm Klassichen Fleckfiebers und dem virus der infectiosen Ektromelie. 2 Path Bakteriol 6:463–472Google Scholar
  9. Schell K (1960) Studies on the innate resistance of mice to infection with mousepox. II. Route of inoculation and resistance; and some observations on the inheritance of resistance. Aust J Exp Biol Med Sci 38:289–300PubMedCrossRefGoogle Scholar
  10. Wallace GD, Buller RML (1985) Kinetics of ectromelia virus (mousepox) transmission and clinical response in C57BL/6J, BALB/cByJ and AKR/J mice. Lab Animal Sci 35:41–46Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • R. M. L. Buller
  • M. Potter
  • G. D. Wallace

There are no affiliations available

Personalised recommendations