Polymorphism and Recombinational Hot Spots in the Murine MHC
Over the past five years enormous progress has been made in the elucidation of the molecular biology of the murine major histocompatibility complex (MHC) (for reviews see Klein et al, 1983; Mengle-Gaw and McDevitt 1985; Steinmetz 1985). Forty-six genes have been cloned and identified from the MHC of the BALB/c mouse and ordered into six gene clusters encompassing more than 1600 kb of DNA (Fig. 1). The largest cluster spans 600 kb of DNA and links the 2 class I genes located in the K region to the 7 class II genes in the I region. A gap of unknown size separates this cluster from a 250 kb cluster located entirely in the S region containing 6 genes unrelated to class I and class II genes. These genes code for the complement components C2, Bf and C4, for the C4-related Slp molecule and for 21-hydroxylase, an enzyme involved in steroid biosynthesis. The second largest cluster, 500 kb in size, links the D to the Qa region and contains 13 class I genes. Finally, 18 class I genes have been mapped into 3 gene clusters, 160, 80 and 40 kb in size, all located in the Tla region.
KeywordsMajor Histocom Laboratory Mouse Strain Murine Major Histocompatibility Complex Independent Recombination Event Hypervariable Minisatellite
Unable to display preview. Download preview PDF.
- Mellor AL, Antoniou J, Robinson PJ (1985) Structure and expression of genes encoding murine Qa-2 class I antigens. Proc Natl Acad Sci USA: in pressGoogle Scholar
- Nathenson SG, Geliebter J, Geier SS, Mashimo H, Hemmi S, Kumar A, McGovern D, Nakagawa M, Pfaffenbach G, Pontarotti P, Zeff R (1985) The study of H-2 major histocompatibility complex mutants reveals structure-function relationships and mechanisms of generation of diversity and polymorphism. In: Streilein et al. (eds) Advances in gene technology: molecular biology of the immune system. Cambridge University Press, Cambridge p37–40Google Scholar
- Steinmetz M (1985) Genes of the immune system. In: Rigby PWJ (ed) Genetic engineering, vol 5 Academic Press, London, in pressGoogle Scholar
- Sun H, Goodenow RS, Hood L (1985) Molecular basis of the dml mutation in the major histocompatibility complex of the mouse: A D/L hybrid gene. J Exp Med: in pressGoogle Scholar