Genetic Variants of Histocompatibility Antigens from Wild Mice
Had it not been for wild mice, the genetic analysis of Mta, a maternally transmitted histocompatibility antigen of mice, would have ended five years ago. Testing 79 inbred strains of laboratory mice, we had identified only two forms of Mta, positive (now known as Mta[α, a]) and negative (Mta[β, a]), and shown that the difference was determined by a maternally transmitted factor, Mtf (Fischer Lindahl et al. 1980; Fischer Lindahl and Hausmann 1983). But then the plethora of genetic variation in wild mice led to the identification of a chromosomal gene, Hmt, involved in Mta expression (Fischer Lindahl et al. 1983), yielded new alleles of Mtf, Hmt, and B2m (Robinson et al. 1984), gave a clearer picture of the roles of Mtf and Hmt in expression of Mta (Fischer Lindahl 1985a), and led to the discovery of new recombinational hot spots in the H-2 complex (Steinmetz et al., submitted). This paper will briefly describe the new strains that are under inbreeding as a result of this work.
KeywordsLaboratory Mouse Cell Surface Antigen Histocompatibility Antigen Wild Mouse Inbred Background
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