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Genetic Diversity of Class II Genes in Wild Mice: Definition of Five Evolutionary Groups by RFLP Analysis of Aα and Aβ

  • E. K. Wakeland
  • R. A. McIndoe
  • T. J. McConnell
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 127)

Abstract

The class II genes of the murine major histocompatibility complex (H-2) are a tightly linked cluster of highly polymorphic genes which encode molecules involved in the recognition of antigen by T lymphocytes. Biochemical analyses of class II molecules have identified two molecules, designated I-A and I-E, which are expressed on the surfaces of antigen presenting cells and B lymphocytes (Cullen et al. 1976; Uhr et al. 1979). Both molecules are integral membrane glycoproteins and each is a heterodimer formed by noncovalent interactions between an alpha (α) and beta (β) subunit.

Keywords

High Performance Liquid Chromatography Tryptic Peptide Evolutionary Group Wild Mouse Restriction Fragment Length Polymorphism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Choi EK, Mcintyre K, Germain RN, Seidman SG (1983) Murine I-Aβ chain polymorphism: nucleotide sequences of three allelic I-Aβ genes. Science 221:283PubMedCrossRefGoogle Scholar
  2. Cullen SE, Freed JH, Nathenson SG (1975) Structural and serological properties of murine Ia alloantigens. Tansplant Rev 30: 236Google Scholar
  3. Duncan WR, Wakeland EK, Klein J (1979) Heterozygosity of H-2 loci in wild mice. Nature 281:322CrossRefGoogle Scholar
  4. Klein J (1975) Biology of the mouse histocompatibility-2 complex. Springer-Verlag, New York.Google Scholar
  5. McConnell TJ, Darby B, Wakeland EK (to be published) Restriction fragment length polymorphisms of class II gene sequences in mice expressing minor structural variants of I-Ak and I-Ap. J ImmunolGoogle Scholar
  6. Nei M, Li WH (1979) Mathematical model for studying genetic variation in terms of restriction endonucleases. PNAS 76:5269PubMedCrossRefGoogle Scholar
  7. Sage RD (1981) Wild mice. In: Foster HL, Small JD, Fox JG (eds) The mouse in biomedical research, vol 1. Academic Press New York p 40Google Scholar
  8. Steinmetz MK, Minard K, Horvath S, et al. (1982) A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature 300:35PubMedCrossRefGoogle Scholar
  9. Steinmetz M, Malissen M, Hood L, et al. (1984) Tracts of high or low sequence divergence in the mouse major histocompatibility complex. EMBO Journal 3:2995PubMedGoogle Scholar
  10. Uhr J, Capra JD, Vitetta ES, Cook RG (1979) Organization of the immune response genes. Science 206:292PubMedCrossRefGoogle Scholar
  11. Wakeland EK, Klein J (1981) The polymorphism of I region encoded antigens among wild mice. In: Reisfeld RA, Ferrone S (eds) Current trends in histocompatibility, Plenum Press New York p322.Google Scholar
  12. Wakeland EK, Klein J (1983) Evidence for minor structural variations of class II genes in wild and inbred mice. J Immunol 130:1280PubMedGoogle Scholar
  13. Wakeland EK, Darby BR (1983) Recombination and mutation of class II histocompatibility genes in wild mice. J Immunol 131:3052PubMedGoogle Scholar
  14. Wakeland EK, Darby BR, Coligan (1985) Localization of structural variations to the α1 and β1 domains. J Immunol 135:391PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • E. K. Wakeland
  • R. A. McIndoe
  • T. J. McConnell

There are no affiliations available

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