Genetic Diversity of Class II Genes in Wild Mice: Definition of Five Evolutionary Groups by RFLP Analysis of Aα and Aβ
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The class II genes of the murine major histocompatibility complex (H-2) are a tightly linked cluster of highly polymorphic genes which encode molecules involved in the recognition of antigen by T lymphocytes. Biochemical analyses of class II molecules have identified two molecules, designated I-A and I-E, which are expressed on the surfaces of antigen presenting cells and B lymphocytes (Cullen et al. 1976; Uhr et al. 1979). Both molecules are integral membrane glycoproteins and each is a heterodimer formed by noncovalent interactions between an alpha (α) and beta (β) subunit.
KeywordsHigh Performance Liquid Chromatography Tryptic Peptide Evolutionary Group Wild Mouse Restriction Fragment Length Polymorphism
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