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Amplification and Rearrangement of DNA Sequences During the Evolutionary Divergence of t Haplotypes and Wild-Type Forms of Mouse Chromosome 17

  • J. Schimenti
  • L. M. Silver
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 127)

Abstract

The most proximal portion of mouse chromosome 17 occurs in a variant form known as a t haplotyper which is present at a high frequency in wild populations of mus domesticus and mus musculus. While t haplotypes have been studied by a number of investigators over the last 50 years, it is only within the last 5 years that we have begun to appreciate the true nature of these unusual genetic elements (for a recent review, see Silver, 1986). A large body of new data from a number of laboratories indicates that all naturally occurring t haplotypes are closely related to each other with a characteristic genomic organization that differs from the wild-type organization of this chromosomal region. (The “wild-type chromosome 17” refers to the non-t-haplotype form normally found in mus domesticus or mus musculus). Within the structurally variant region that defines t haplotypes (approximately 20–30,000 kb of DNA encompassing the T locus and the entire MHC), are many normally functioning genes interspersed with a number of independent “mutant loci” that mediate the characteristic t haplotype effects on fertility and development.

Keywords

Mouse Chromosome Transmission Ratio Distortion Lambda Clone Relative Inversion Small Central Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • J. Schimenti
  • L. M. Silver

There are no affiliations available

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