Amplification and Rearrangement of DNA Sequences During the Evolutionary Divergence of t Haplotypes and Wild-Type Forms of Mouse Chromosome 17
The most proximal portion of mouse chromosome 17 occurs in a variant form known as a t haplotyper which is present at a high frequency in wild populations of mus domesticus and mus musculus. While t haplotypes have been studied by a number of investigators over the last 50 years, it is only within the last 5 years that we have begun to appreciate the true nature of these unusual genetic elements (for a recent review, see Silver, 1986). A large body of new data from a number of laboratories indicates that all naturally occurring t haplotypes are closely related to each other with a characteristic genomic organization that differs from the wild-type organization of this chromosomal region. (The “wild-type chromosome 17” refers to the non-t-haplotype form normally found in mus domesticus or mus musculus). Within the structurally variant region that defines t haplotypes (approximately 20–30,000 kb of DNA encompassing the T locus and the entire MHC), are many normally functioning genes interspersed with a number of independent “mutant loci” that mediate the characteristic t haplotype effects on fertility and development.
KeywordsMouse Chromosome Transmission Ratio Distortion Lambda Clone Relative Inversion Small Central Region
Unable to display preview. Download preview PDF.
- Herrmann B, Bucan M, Mains P, Frischauf A-M, Silver LM, Lehrach H (1986) Analysis of the proximal portion of the mouse t complex: Evidence for a second inversion within t haplotypes. Cell, in press.Google Scholar
- Olds-Clarke P, Peitz B (in press) Fertility of sperm from t/+ mice: Evidence that +-bearing sperm are dysfunctional. Genetical ResearchGoogle Scholar
- Sarvetnick N, Mann E, Mains P, Elliott R, Silver LM (1986) Nonhomologous pairing in mouse t haplotype heterozygotes can produce recombinant chromosomes with adjacent duplications and deletions.Google Scholar