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λ1 Bearing Antibodies Against the α(1–3) and α(1–6)Glycosidic Linkages of the B1355 Dextran in Wild Mice

  • D. Juy
  • J. L. Guénet
  • F. Bonhomme
  • P.-A. Cazenave
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 127)

Abstract

The immune response to the α(1–3) glycosidic linkage of the dextran (Dex) B1355 has been shown to be linked to the Igh locus (Blomberg et al. 1972, Riblet et al. 1975). In laboratory strains only mice with the Igha allotypic haplotype produce anti-α(l-3) Dex antibodies. This response is characterized by antibodies bearing the λ1 light chain (Carson and Weigert, 1973). The majority of these antibodies express a recurrent idiotypic specificity (IdX) present on both J558 and M104 myeloma proteins in addition to either IdI 558 or IdI 104 recurrent individual idiotypic specificities (Hansburg 1977, Clevinger et al. 1980, Stohrer et al. 1983a). At the clonal level, IdI 558 and IdI 104 determinants were not found to be present on the same molecule (Clevinger et al. 1980, Kearney et al. 1983).

Keywords

Wild Mouse Idiotypic Determinant Light Chain Isotype Idiotypic Specificity IghV Locus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Amor M, Guenet JL, Bonhomme F, Cazenave PA (1983) Genetic polymorphism of λ1 and λ3 immunoglobulin light chains in the mus subgenus. Eur J Immunol 13:312–317PubMedCrossRefGoogle Scholar
  2. Blomberg B, Geckeier WR, Weigert M (1972) Genetics of the antibody response to Dextran in mice. Science 177:178–181PubMedCrossRefGoogle Scholar
  3. Carson D, Weigert M (1973) Immunological analysis of the cross-reacting idiotopes of mouse myeloma proteins with anti-Dextran activity and normal anti-Dextran antibodies. Proc Natl Acad Sci USA 70:235–239PubMedCrossRefGoogle Scholar
  4. Clevinger B, Schilling J, Hood L, Davie J (1980) Structural correlates of crossreactive and individual idiotypic determinants on murine antibodies to α(1–3)Dextran. J Exp Med 151:1059–1070PubMedCrossRefGoogle Scholar
  5. Geckeler W, Faversham J, Cohn M (1978) On a regulatory gene controlling the expression of the murine λ1 light chain. J Exp Med 148:1122–1136PubMedCrossRefGoogle Scholar
  6. Hansburg D, Briles DE, Davie J (1977) Analysis of the diversity of murine antibodies to Dextran B1355. II.Demonstration of multiple idiotypes with variable expression in several strains. J Immunol 119:1406–1412PubMedGoogle Scholar
  7. Juy D, Cazenave PA (1985) Igh restriction of the anti-α(1–3)Dextran response: polyclonal B cell activators induce the synthesis of anti-α(1–3)Dextran antibodies in lymphocytes from Igha mice only. Eur J Immunol 135:1239–1244Google Scholar
  8. Kearney JF, Pollock BA, Stohrer R (1983) Analysis of idiotypic heterogeneity in the anti-α(1–3)Dextran and anti-phosphorylcholine responses using monoclonal anti-idiotype antibodies. “Immune networks” Ed C. Bona and H. Kohler. Annals of the NY Acad of Scicnes 418:151–170CrossRefGoogle Scholar
  9. Kindt TJ, Gris C, Guenet JL, Bonhomme F, Cazenave PA (1985) Lambda light chain constant and variable gene complements in wild-derived inbred mouse strains. Eur J Immunol 15:535–540PubMedCrossRefGoogle Scholar
  10. Primi D, Sanchez P, Cazenave PA (1984) Selective and polyclonal induction of high level of λ1 light chain-bearing immunoglobulins in BALB/c and SJL mice. Eur J Immunol 14:1159–1162PubMedCrossRefGoogle Scholar
  11. Riblet R, Blomberg B, Weigert M, Lieberman R, Taylor BA, Potter M (1975) Genetics of mouse antibodies. I.Linkage of the Dextran response locus YH-Dex to allotype. Eur J Immunol 5:775–777PubMedCrossRefGoogle Scholar
  12. Sanchez P, Primi D, Levi-Strauss M, and Cazenave PA (1985) The regulatory locus rλ1 affects the level of λ1 light chain synthesis in lipopolysaccharide-activated lymphocytes but not the frequency of λ1-positive B cell precursors. Eur J Immunol 15:66–72PubMedCrossRefGoogle Scholar
  13. Stohrer R, Kearney JF (1983a) Fine idiotype analysis of B cell precursors in the T-dependent and T-independent responses to α(1–3) Dextran responses in BALB/c mice. J Exp Med 158:2081–2094PubMedCrossRefGoogle Scholar
  14. Stohrer R, Lee MC, Kearney JF (1983b) Analysis of the anti-α(1–3) Dextran response with monoclonal anti-idiotype antibodies. J Immunol 131:1375–1380PubMedGoogle Scholar
  15. Scott CL, Potter M (1984) Variation in VX genes in the genus Mus. J Immunol 132:2638–2643PubMedGoogle Scholar
  16. Weiler E, Lehle G, Wilke J, Weiler YJ (1984) Isogeneic anti-idiotype repertoire and modulation of idiotype expression in the anti-Dextran system. In “Idiotypy in Biology and Medicine” 12:203–218Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • D. Juy
  • J. L. Guénet
  • F. Bonhomme
  • P.-A. Cazenave

There are no affiliations available

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