A Comparative Analyis of the Anti-Phosphorylcholine Response of CLA and BALB/c Mice
Wild mice have been used in basic research as a source of new genetic material and in the generation of a Mus phylogenetic tree. Studies of this nature have used morphologic and chromosomal polymorphisms to define the genealogic relationship of various Mus species, as well as to define the origins of inbred laboratory mice. It is now clear that the common inbred strains of mice are derived from a small number of progenitors (Marshall, 1981; Yonekowa, 1980; Ferris, 1982). Given the limited genetic pool from which inbred mice have been derived, the question arises whether the immune phenomena described in inbred mice accurately reflect those found in more distantly related populations of mice. Therefore, comparison of inbred immune responses with those observed in outbred populations of mice may foster an understanding of the processes which shape an individual’s immune repertoire.
KeywordsInbred Mouse Wild Mouse Immunoglobulin Heavy Chain Gene Competitive Inhibition Assay Lambda Gene
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