The X-24 VH Gene Family in Inbred Mouse Strains and Wild Mice
The germline content of immunoglobulin (Ig) heavy and light chain variable region genes is one important source of antibody diversity; thus a large germline repetoire of these genes provides a potential capability to respond to a wide variety of antigens independent of subsequent somatic diversification. Immunoglobulin variable region genes appear to have evolved at a more rapid rate than many other proteins (Wilson 1977), which might be expected in a system where selection favors increased diversity. Examining evolutionary changes in immunoglobulin multigene families provides an opportunity to study the rate at which this system is evolving and permits an examination of the relative contribution of point mutations, recombinational events and gene duplications to the generation of germline diversity. The Ig repetoire of inbred Mus musculus, which has been extensively studied (for a review, see Honjo 1985, Hood 1985), represents an ideal model for such studies.
KeywordsInbred Strain Wild Mouse Myeloma Protein Variable Region Gene Restriction Fragment
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