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Evolution of Immunologically Important Genes in the Genus Mus

  • E. Jouvin-Marche
  • A. Cuddihy
  • M. Heller
  • S. Butler
  • J. N. Hansen
  • S. Rudikoff
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 127)

Abstract

It is somewhat surprising, considering the pre-eminent position the laboratory mouse has held in biological research, how little is known about this species as a whole, with the exception of members of the subgenus Mus, Some of the European and Asian subspecies of Mus have been studied by classical morphologic analysis (Marshall and Sage 1981) and biochemical genetics employing protein polymorphisms (Bonhomme 1978a, 1984; Sage 1981). However, there exists to date very little data at the protein or nucleic acid sequence levels to provide information pertaining to actual patterns of gene evolution or relationships between subspecies or subgenera.

Keywords

Immunoglobulin Heavy Chain Complementarity Determine Region Wild Mouse VK24 Gene Antigen Binding Specificity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bonhomme F, Britton-Davidian J, Thaler L, Triantaphyllides C (1978a) Sur l’existence en Europe de quatte groupes de Souris (genre Mus L.) de rang espece et semi-espece, demontree par la genetique biochimique. CR Hebd Seances Acad Sci Ser D 287:631–633Google Scholar
  2. Bonhomme F, Calahen J, Britton-Davidson J, Chapman VM, Moriwaki K, New E, Thaler L (1984) Biochemical diversity and evolution in the genus Mus. Biochem Genetics 22:275–301CrossRefGoogle Scholar
  3. Brodeur PH, Riblet R (1984) The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes. Eur J Immunol 14: 922–926PubMedCrossRefGoogle Scholar
  4. Chien Y-H, Gascoigne NRJ, Kavaler J, Lee NE, Davies MM (1984) Somatic recombination in a murine T-cell receptor gene. Nature 309:322–326PubMedCrossRefGoogle Scholar
  5. Cory S, Typer BM, Adams JM (1981) Sets of immunoglobulin V genes homologous to ten cloned V sequences: implications for the number of germline V genes. J Mol Appl Genet 1:103PubMedGoogle Scholar
  6. Early P, Huang H, Davis M, Calame K, Hood L (1980) An immunoglobulin heavy chain variable gene is generated from three segments of DNA: VH, D, and JH. Cell 19:981PubMedCrossRefGoogle Scholar
  7. Emorine L, Kuehl M, Weir L, Leder P, Max E (1983) A conserved sequence in the immunoglobulin JK-CK intron: possible enhancer element. Nature 304:447–449PubMedCrossRefGoogle Scholar
  8. Gascoigne NRJ, Chien Y-H, Becker DM, Kavaler J, Davis MM (1984) Genomic organisation and sequence of T-cell receptor β-chain constant and joining region genes. Nature 310:387–391PubMedCrossRefGoogle Scholar
  9. Hedrick S, Nielsen E, Kavaler J, Cohen D, Davis M (1984b) Sequence relationships betweenputative T-cell receptor polypeptides and immunoglobulins. Nature 308:153–158PubMedCrossRefGoogle Scholar
  10. Joho R, Weissman IL, Early P, Cole J, Hood L (1980) Organization of K light chain genes in germline and somatic tissue. Proc Natl Acad Sci USA 77:1106–1110PubMedCrossRefGoogle Scholar
  11. Joho R, Gershenfeld H, Weissman TL (1984) Evolution of a multigene family of VK germline genes. EMBO J 3:185–191PubMedGoogle Scholar
  12. Malissen M, Minard K, Mjoisness S, Kronenberg M, Goverman J, Hunkapiller T, Prystowsky MB, Yoshikai Y, Fitch F, Mak TW, Hood L (1984) Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the β polypeptide. Cell 37:1101–1110PubMedCrossRefGoogle Scholar
  13. Marshall JT, Sage RD (1981) Taxonomy of the house mouse. Symp Zool Soc Lond 47:15–25Google Scholar
  14. Max EE, Seidman JG, Leder P (1979) Sequences of five recombination sites encoded close to an immunoglobulin K constant region gene. Proc Natl Acad Sci USA 76:3450PubMedCrossRefGoogle Scholar
  15. Sage RD (1981) Wild Mice. The mouse in biomedical research. 1:40–90Google Scholar
  16. Tonegawa S (1983) Somatic generation of antibody diversity. Nature 302:575–581PubMedCrossRefGoogle Scholar
  17. Tunnacliffe A, Kefford R, Milstein C, Forsta A, Rabbitts TH (1985) Sequence and evolution of the human T-cell antigen receptor β chain genes. Proc Natl Acad Sci USA 82:5068–5072PubMedCrossRefGoogle Scholar
  18. Yanagi, Y, Yoshikai Y, Leggett K, Clark S, Aleksander I, Mak T (1984) A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature 308:145–149PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • E. Jouvin-Marche
  • A. Cuddihy
  • M. Heller
  • S. Butler
  • J. N. Hansen
  • S. Rudikoff

There are no affiliations available

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