Alleles of β-Glucuronidase Found in Wild Mice
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β-Glucuronidase (Gus) has been extensively studied in the mouse as a model of mammalian gene regulation. The structural gene maps to chromosome 5 and variation for the regulation of Gus gene expression cosegregates with the structural locus. The regulatory phenotypes include variation in systemic levels of gene expression (Pfister et al., 1985), variation in testosterone induction of kidney β-glucuronidase (Palmer et al., 1983; Swank et al., 1973) and variation in Gus expression within individual organs. The various structural and regulatory phenotypes which cosegregate at the GUS locus are designated as haplotypes [Gus] and the different regulatory phenotypes have been designated as separate elements of the haplotype complex (Table 1) (Paigen, 1979).
KeywordsRecombinant Inbred Congenic Strain Heat Inactivation Enzyme Structure Testosterone Treatment
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