MHC Polymorphism in Island Populations of Mice

  • F. Figueroa
  • H. Tichy
  • R. J. Berry
  • J. Klein
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 127)


The major histocompatibility complex of the house mouse, Mus domestieus, contains two highly polymorphic class I loci (H-2K and H-2D) and two or three highly polymorphic class II loci (H-2A ß, H-2E ß, and perhaps H-2A α; see Klein et al. 1983, Klein and Figueroa 1981). Any given small population of wild mice (e.g., mice living in a farm complex) may contain from 5 to 10 alleles at each of the polymorphic loci, all occurring at appreciable frequencies (Figueroa et al. 1982). The total number of alleles at a given polymorphic locus probably exceeds 100 and virtually all wild mice thus far captured in continental Europe or North America are heterozygous at the polymorphic loci.


Major Histocompatibility Complex Polymorphic Locus House Mouse Wild Mouse Mouse Population 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • F. Figueroa
  • H. Tichy
  • R. J. Berry
  • J. Klein

There are no affiliations available

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