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Correlating Pharmacokinetics and Pharmacodynamics of Benzodiazepines: Problems and Assumptions

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Clinical Pharmacology in Psychiatry

Part of the book series: Psychopharmacology Series ((PSYCHOPHARM,volume 3))

Abstract

The development of reliable and specific methods for quantitation of benzodiazepine derivatives in body fluids has led to the accumulation of considerable knowledge of their pharmacokinetic properties in humans and in other species (Klotz et al. 1980; Guentert 1984; Greenblatt et al. 1983a,b; Greenblatt and Shader 1985 a). These data include the kinetic properties in healthy individuals, the influence of physiologic states and disease processes on benzodiazepine disposition, and alterations in kinetics due to drug interactions. The study of benzodiazepine pharmacokinetics has elucidated much about the general mechanisms controlling the biotransformation of foreign chemicals, and factors influencing drug disposition.

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Author information

Authors and Affiliations

  1. Division of Clinical Pharmacology, Tufts University School of Medicine and New England Medical Center Hospital, Boston, MA, 0211, USA

    D. J. Greenblatt, H. L. Friedman & R. I. Shader

  2. Department of Psychiatry, Tufts University School of Medicine and New England Medical Center Hospital, Boston, MA, 0211, USA

    D. J. Greenblatt, H. L. Friedman & R. I. Shader

  3. Department of Medicine, Tufts University School of Medicine and New England Medical Center Hospital, Boston, MA, 0211, USA

    D. J. Greenblatt, H. L. Friedman & R. I. Shader

Authors
  1. D. J. Greenblatt
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  2. H. L. Friedman
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  3. R. I. Shader
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Institute of Medical Biology, University of Tromsø School of Medicine, N-9001, Tromsø, Norway

    Svein G. Dahl Cand Real, Dr. Philos. (Professor of Pharmacology) (Professor of Pharmacology)

  2. Department of Clinical Pharmacology, School of Medicine, Odense University, DK-5000, Odense C, Denmark

    Lars F. Gram MD (Professor of Clinical Pharmacology) (Professor of Clinical Pharmacology)

  3. Clinical Neuroscience Branch, National Institute of Mental Health, Building 10, Room 4N214, 20205, Bethesda, MD, USA

    Steven M. Paul MD (Chief) (Chief)

  4. Section on Clinical Psychopharmacology, Laboratory of Clinical Science, Building 10, National Institute of Mental Health, 20205, Bethesda, MD, USA

    William Z. Potter MD, PhD (Chief) (Chief)

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© 1987 Springer-Verlag Berlin Heidelberg

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Greenblatt, D.J., Friedman, H.L., Shader, R.I. (1987). Correlating Pharmacokinetics and Pharmacodynamics of Benzodiazepines: Problems and Assumptions. In: Dahl, S.G., Gram, L.F., Paul, S.M., Potter, W.Z. (eds) Clinical Pharmacology in Psychiatry. Psychopharmacology Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71288-3_7

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  • DOI: https://doi.org/10.1007/978-3-642-71288-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71290-6

  • Online ISBN: 978-3-642-71288-3

  • eBook Packages: Springer Book Archive

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