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Chronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects?

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Clinical Pharmacology in Psychiatry

Part of the book series: Psychopharmacology Series ((PSYCHOPHARM,volume 3))

Abstract

The treatment for most psychotic patients was largely ineffectual and care primarily custodial until the discovery of the antipsychotic properties of chlorpromazine in 1953. Ten years later Carlsson and Lindqvist (1963) discovered that antipsychotic drugs (neuroleptics) exert a specific action on central catecholamine systems, and hypothesized that they produced their effects by blocking catecholamine receptors in catecholamine-innervated sites. They further posited that the receptor blockade resulted in an increase in catecholamine neuronal activity which was mediated through long-loop feedback pathways from forebrain regions innervated by catecholamine neurons (Carlsson and Lindqvist 1963). This concept was a major impetus behind the last two decades of research on the mode of action of neuroleptics. During this time the dopamine (DA) system has been the primary focus of attention and DA receptor blockers have continued to be the treatment of choice for the major symptoms of psychosis (Klein et al. 1980).

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Authors and Affiliations

  1. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510-8066, USA

    A. S. Freeman & B. S. Bunney

  2. Department of Pharmacology, Yale University School of Medicine, New Haven, CT, 06510-8066, USA

    A. S. Freeman & B. S. Bunney

Authors
  1. A. S. Freeman
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  2. B. S. Bunney
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Institute of Medical Biology, University of Tromsø School of Medicine, N-9001, Tromsø, Norway

    Svein G. Dahl Cand Real, Dr. Philos. (Professor of Pharmacology) (Professor of Pharmacology)

  2. Department of Clinical Pharmacology, School of Medicine, Odense University, DK-5000, Odense C, Denmark

    Lars F. Gram MD (Professor of Clinical Pharmacology) (Professor of Clinical Pharmacology)

  3. Clinical Neuroscience Branch, National Institute of Mental Health, Building 10, Room 4N214, 20205, Bethesda, MD, USA

    Steven M. Paul MD (Chief) (Chief)

  4. Section on Clinical Psychopharmacology, Laboratory of Clinical Science, Building 10, National Institute of Mental Health, 20205, Bethesda, MD, USA

    William Z. Potter MD, PhD (Chief) (Chief)

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© 1987 Springer-Verlag Berlin Heidelberg

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Freeman, A.S., Bunney, B.S. (1987). Chronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects?. In: Dahl, S.G., Gram, L.F., Paul, S.M., Potter, W.Z. (eds) Clinical Pharmacology in Psychiatry. Psychopharmacology Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71288-3_26

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  • DOI: https://doi.org/10.1007/978-3-642-71288-3_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71290-6

  • Online ISBN: 978-3-642-71288-3

  • eBook Packages: Springer Book Archive

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