Abstract
Serotonin-S2 receptor sites were first described in studies in which 3H-spiperone was used in frontal cortical membrane preparations (Leysen et al. 1978; Peroutka and Snyder 1979). The receptor binding sites were further characterized and could be better distinguished by using the more selective serotonin antagonist 3H-ke-tanserin (Leysen et al. 1982). Serotonin-S2 receptors were shown to have a role in serotonin agonist-induced behavioral excitation and discriminative stimulus effects in rodents, and also to mediate serotonin-induced vasoconstriction and platelet function. Recently it has been shown that inositol phospholipid turnover forms part of the signal transducing system coupled to serotonin-S2 receptor sites (for review see Leysen et al. 1984).
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Leysen, J.E., van Gompel, P., Gommeren, W., Laduron, P.M. (1987). Differential Regulation of Dopamine-D2 and Serotonin-S2 Receptors by Chronic Treatment with the Serotonin-S2 Antagonists, Ritanserin, and Setoperone. In: Dahl, S.G., Gram, L.F., Paul, S.M., Potter, W.Z. (eds) Clinical Pharmacology in Psychiatry. Psychopharmacology Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71288-3_25
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