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Drugs Useful in Angioplasty

  • G. L. Wolf
Conference paper
Part of the Radiology Today book series (RADIOL.TODAY, volume 4)

Abstract

Endothelial trauma is an inevitable consequence of passing guidewires and catheters through blood vessels [1]. Angioplasty produces more extensive trauma — “controlled damage” — to a diseased blood vessel. The functions of the endothelium include providing a steady flow of vasodilator substances and resisting both platelet aggregation and thrombosis. Atherosclerosis damages the endothelium and enhances the response to vasoconstrictors and thrombogenic factors. The process of mechanically enlarging the lumen of a diseased artery with a balloon is only therapeutically effective if the potential complications of thrombosis, platelet aggregation, and vasospasm can be controlled. Any one of these adverse events tends to make the others more likely. Finally, for angioplasty to be cost effective, it must be durable. Restenosis is also a process initiated by the controlled damage of angioplasty [2, 3]. There are pharmacologic agents that oppose each of the potential complications of percutaneous transluminal angioplasty (PTA) — thrombosis, platelet aggregation, and vasospasm — and that probably improve the outcome of PTA.

Keywords

Platelet Aggregation Control Damage Arterial Vasodilator Direct Vasodilator Prevent Platelet Aggregation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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    US Pharmacopeia Drug Information (1985) Heparin, 5th edn:651-656Google Scholar
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    LeVeen RF, Wolf GL et al. (1985) Angioplasty-induced vasospasm in rabbit model: mechanisms and treatment. Invest Radiol 20: 938–944PubMedCrossRefGoogle Scholar
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Copyright information

© Springer-Verlag Berlin, Heidelberg 1987

Authors and Affiliations

  • G. L. Wolf

There are no affiliations available

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