Drugs Useful in Angioplasty
Endothelial trauma is an inevitable consequence of passing guidewires and catheters through blood vessels . Angioplasty produces more extensive trauma — “controlled damage” — to a diseased blood vessel. The functions of the endothelium include providing a steady flow of vasodilator substances and resisting both platelet aggregation and thrombosis. Atherosclerosis damages the endothelium and enhances the response to vasoconstrictors and thrombogenic factors. The process of mechanically enlarging the lumen of a diseased artery with a balloon is only therapeutically effective if the potential complications of thrombosis, platelet aggregation, and vasospasm can be controlled. Any one of these adverse events tends to make the others more likely. Finally, for angioplasty to be cost effective, it must be durable. Restenosis is also a process initiated by the controlled damage of angioplasty [2, 3]. There are pharmacologic agents that oppose each of the potential complications of percutaneous transluminal angioplasty (PTA) — thrombosis, platelet aggregation, and vasospasm — and that probably improve the outcome of PTA.
KeywordsPlatelet Aggregation Control Damage Arterial Vasodilator Direct Vasodilator Prevent Platelet Aggregation
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