Usefulness of Regional Bone Measurements in Patients with Osteoporotic Fractures
The measurement of the bone mineral content of the skeleton has revolutionized the study of osteoporosis in the last 25 years. Initially, methods of grading the degree of bone loss from simple radiographs of the lumbar spine  and the femoral neck  were described. The poor precision of these techniques  led to the first method for measuring bone mass by the absorption of monoenergetic photons . The distal third of the radius became the most widely used site , but methods have also been reported for os calcis , femur , and metacarpals . It recently became possible to examine the bones of the spine using a dual isotope technique of photon absorptiometry . Either a single dichromatic source  or two monochromatic sources  are used to measure the 2nd, 3rd, and 4th lumbar vertebrae, allowing an estimate of the axial trabecular bone mineral content to be made .
KeywordsBone Mineral Density Bone Mass Vertebral Fracture Osteoporotic Fracture Bone Mineral Content
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- 2.Singh M, Nagrath AR, Maini PS (1970) Changes in the trabecular pattern of the upper end of the femur as an index of osteoporosis. J Bone Joint Surg (Am) 52: 457–467Google Scholar
- 3.Mazess RB (1979) Non-invasive measurement of bone. In: Barzel US (ed) Osteoporosis II. Grune and Stratton, New York, pp 5–26Google Scholar
- 9.Reed GW (1966) The assessment of bone mineralisation from the relative transmission of 241 Am and 137Cs radiations. Phys Med Biol 11: 174Google Scholar
- 10.Mazess RB, Ort M, Judy P, Mather W (1970) Absorptiometric bone mineral determination using 153Gd. In: Cameron JR (ed) Proceedings of bone measurements conference (Conference 700515 ). US Atomic Energy Commission, Washington DC, pp 308–312Google Scholar
- 14.Gotfredsen A, Borg J, Christiansen C (1983) Total body bone mineral measured by dual photon absorptiometry. Calcif Tissue Int 35 s: A2Google Scholar
- 16.Nilas L, Nergaard H, Pødenphant J, Gotfredsen A, Christiansen C (1987) Bone composition in the distal forearm. Scand J Clin Lab Invest 47 (to be published)Google Scholar
- 20.Nilas L, Podenphant J, Riis BJ, Christiansen C (1987) Usefulness of regional bone measurements in patients with osteoporotic fractures of the spine and distal forearm. J Nucl Med (to be published )Google Scholar
- 25.Smith DM, Johnston CC, Yu P-L (1972) In vivo measurement of bone mass. Its use in demineralized states such as osteoporosis. JAMA 219: 325–329Google Scholar
- 31.Lindsay R, Aitken JM, Anderson JB, Hart DM, MacDonald EB, Clarke AC (1976) Long-term prevention of postmenopausal osteoporosis by oestrogen. Lancet i: 1038–1041Google Scholar
- 32.Christianen C, Christensen MS, Transbøl I (1981) Bone mass in postmenopausal women after withdrawal of oestrogen/gestagen replacement therapy. Lancet i: 459–461Google Scholar