Skip to main content

Pharmakologie der Benzodiazepine

  • Conference paper
ZAK Zürich

Zusammenfassung

Der Begriff Benzodiazepine umfaßt im strengen Sinn chemische Verbindungen, die als Grundgerüst das bizyklische Benzodiazepinringsystem enthalten (aromatischer Benzolring gekoppelt an einen Siebenerring mit 2 Stickstoffen, meist in der 1,4-Stellung). Im pharmakologischen Sprachgebrauch wird der Begriff in einem sehr weiten Sinn verwendet; er umfaßt Verbindungen mit dem Benzodiazepin- oder einem verwandten Ringsystem, die ein charakteristisches Wirkungsprofil besitzen (Definition s. nächster Abschnitt). Der erste Vertreter dieser Substanzklasse war Chlordiazepoxyd (Librium). Heute sind mindestens 30 Substanzen, die dieser Definition entsprechen, weltweit im Handel erhältlich. In den vergangenen 20 Jahren haben sich die Benzodiazepine zu den am häufigsten verschriebenen Medikamenten entwickelt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Costa E, Di Chiara G, Gessa GL (1981) GABA and benzodiazepine receptors. Adv Biochem Psychopharmacol 26

    Google Scholar 

  2. Cumin R, Bonetti EP, Scherschlicht R, Haefely WE (1982) Use of the specific benzodiazepine antagonist, Ro 15–1788, in studies of physiological dependence on benzodiazepines. Experientia 38:833–834

    Article  CAS  PubMed  Google Scholar 

  3. Haefely WE (1978) Behavioral and neuropharmacological aspects of drugs used in anxiety and related states. In: Lipton MA, DiMascio A, Killam KF (eds) Psychopharmacology: A generation of progress. Raven, New York, pp 1359–1374

    Google Scholar 

  4. Haefely W (1983) Tranquilizers. In: Grahame-Smith DG, Hippius H, Winokur G (eds) Psychopharmacology, vol 1, part 1: Basic preclinical neuropharmacology. Excerpta Medica, Amsterdam, pp 107–151

    Google Scholar 

  5. Haefely W (1983) The biological basis of benzodiazepine actions. J Psychoactive Drugs 15:19–39

    Article  CAS  PubMed  Google Scholar 

  6. Haefely W (1983) Actions and interactions of benzodiazepine agonists and antagonists at GABAergic synapses. In: Bowery N (ed) Actions and interactions of GABA and benzodiazepines. Raven, New York

    Google Scholar 

  7. Haefely W (1983) Antagonists of benzodiazepines: Functional aspects. In: Biggio G, Costa E (eds) Benzodiazepine recognition site ligands: Biochemistry and pharmacology. Raven, New York

    Google Scholar 

  8. Haefely W, Polc P (1983) Electrophysiological studies on the interaction of anxiolytic drugs with GABAergic mechanisms. In: Malick JB, Enna SJ, Yamamura HI (eds) Anxiolytics: Neurochemical, behavioral and clinical perspectives. Raven, New York, pp 113–145

    Google Scholar 

  9. Haefely W, Pieri L, Polc P, Schaffner R (1981) Genral pharmacology and neuropharmacology of benzodiazepine derivatives. In: Hoffmeister F, Stille G (eds) Anxiolytics, geronto psychophar-macological agents, and psycho motor stimulants. Springer, Berlin Heidelberg New York (Handbook of experimental pharmacology, vol 55/II, pp 13–262)

    Google Scholar 

  10. Haefely W, Polc P, Pieri L, Schaffner R, Laurent JP (1983) Neuropharmacology of benzodiazepines: Synaptic mechanisms and neural basis of action. In: Costa E (ed) The benzodiazepines: From molecular biology to clinical practice. Raven, New York, pp 21–66

    Google Scholar 

  11. Hunkeler W, Möhler H, Pieri L et al (1981) Selective antagonists of benzodiazepines. Nature 290:514–516

    Article  CAS  PubMed  Google Scholar 

  12. Polc P, Bonetti EP, Schaffner R, Haefely W (1982) A three-state model of the benzodiazepine receptor explains the interactions between the benzodiazepine antagonist Ro 15–1788, benzodiazepine tranquilizers, β-carbolines, and phenobarbitone. Naunyn Schmiedebergs Arch Pharmacol 321:260–264

    Article  CAS  PubMed  Google Scholar 

  13. Usdin E, Skolnick P, Tallman JF, Greenblatt D, Paul SM (1982) Pharmacology of benzodiazepines. MacMillan, London

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Haefely, W. (1986). Pharmakologie der Benzodiazepine. In: Hossli, G., Frey, P., Kreienbühl, G. (eds) ZAK Zürich. Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine, vol 188. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71269-2_43

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71269-2_43

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16618-4

  • Online ISBN: 978-3-642-71269-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics