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Histopathological and Morphometrical Analysis Applied to Skin Changes in NMRI Mice Induced by Dithranol (Anthranil) and its Acyl Analogs

  • V.-M. Kosma
  • Y. Collan
  • A. Naukkarinen
  • M.-L. Aalto
  • P. Männistö
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 9)

Abstract

Histology and morphometric changes in skin lesions of NMRI mice caused by dithranol and its acyl analogs, with and without pretreatment with dimethylbenzanthracene (DMBA) are described. The course of neoplastic progression seems to have three distinct phases (normal skin, hyperplasia, papilloma), each characterized by typical architectural and cellular changes. The parameters reflecting the nuclear size increased in the above order and the differences between the groups were highly significant. Nuclear shape changes did not take place, as shown by the almost constant form factor. The study demonstrates the value of the morphometric methodology in characterizing quantitative nuclear changes in mouse skin models.

Key words

Nuclear morphometry Epidermal hyperplasia Epidermal papilloma Dithranol Butantrone 

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References

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • V.-M. Kosma
    • 1
  • Y. Collan
    • 1
  • A. Naukkarinen
    • 1
  • M.-L. Aalto
    • 1
  • P. Männistö
    • 2
  1. 1.Department of PathologyUniversity of KuopioKuopioFinland
  2. 2.Research CenterOrion Pharmaceutical Co.EspooFinland

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