Changes of Vascular Reactivity Induced by Lead

  • L. Caprino
  • A. Zenobi
  • G. Togna
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 9)


The “in vitro” activity of lead on adenosine diphosphate (ADP) breakdown and on prostacyclin (PGI2)-like activity has been investigated. The metal reduces ADP clearance and the PGI2 activity promoted by arterial tissue. This effect could be attributed to the inhibition of vessel-wall ectoenzymes, which play an important role in the vascular reactivity.

Key words

Lead Adenosine diphosphate degradation Prostacyclin Blood vessel 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • L. Caprino
    • 1
  • A. Zenobi
    • 2
  • G. Togna
    • 2
  1. 1.Institute of PharmacologyCatholic UniversityI-RomeItaly
  2. 2.Institute of HygieneCatholic UniversityI-RomeItaly

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