Differences in the Induction of Autoimmune Responses in A.SW/SnJ Mice by Various Agents
Susceptibility to certain drug-induced immunological reactions is under the genetic control of the major histocompatibility complex (MHC). Previously, ten inbred murine strains bearing different H-2 (murine MHC) haplotypes were screened for autoimmune responses to HgC12, gold sodium thiomalate (GST) and D-penicillamine. Only one of these strains, A.SW/SnJ (H-2s), developed antinuclear antibodies (ANA) in response to treatment with all three agents. In the present study the ability of this strain to develop ANA in response to treatment with procainamide (P) and hydralazine (H), two drugs which frequently induce ANA in humans, was examined Groups of 4-to 5-month-old A.SW/SnJ and C3H/HeSnJ (a resistant strain) mice of both sexes were given daily P (200 mg/kg) or H (40 mg/kg) in drinking water, or GST weekly (10 mg/kg im; positive control) with appropriate controls. After 4 months of treatment, A.SW mice were given the lipid A portion of lipopolysaccharide (Lipid A-LPS), a polyclonal B cell activator, 25 μg ip twice weekly for an additional 4 months along with the drug treatments. Induction of ANA occurred only in GST-treated A.SW/SnJ mice, regardless of Lipid A-LPS treatment. These results suggest that the H-2 controlled sensitivity of A.SW strain is antigen-specific.
Key wordsMajor histocompatibility complex Mercury chloride Gold sodium thiomalate d-penicillamine Hydralazine Procainamide Autoimmunity
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- Robinson CJG, Egorov I, Balazs T (1983) Strain differences in the induction of antinuclear antibodies by mercuric chloride, gold sodium thiomalate and D-penicillamine in inbred mice. Fed Proc 42: 12–13Google Scholar