Skip to main content

Nifedipine Induces Intense Nausea and Vomiting in Young, Healthy Volunteers

  • Conference paper
  • 164 Accesses

Part of the Archives of Toxicology book series (TOXICOLOGY,volume 9)

Abstract

Nifedipine (NIF) is a new calcium antagonist, which is already widely used as an antianginal and antihypertensive drug. In general NIF is well tolerated (Terry 1982), but in this study surprisingly high incidence of nausea and vomiting after ingestion of NIF was observed.

Ten healthy volunteers (age 21–24 y) participated in a pharmacokinetic cross-over study on two slow-release NIF tablets and two liquid-filled NIF capsules. After 8 h of fasting, 20 mg of NIF was given orally; eating was allowed 4 h later. Each volunteer stated the side effects and their duration and intensity. Before the study volunteers were informed about the possibility of headache, flushing of the skin and dizziness.

All the volunteers experienced side effects. The most common (9/10) and the most intense untoward effect of NIF was headache, which was at its worst 4–8 h after ingestion of drugs. One volunteer withdrew because of unbearable nausea, vomiting and weakness; also the others felt nauseous (6/9), and 4 of them vomited. These symptoms did not begin until 5 h after the administration of the drugs, and after the first meal, which is very late compared to the rapid absorption (Tmax 1–2 h) and elimination (T1/2 1–3 h) of the active principle (Foster et al. 1983). In 22 previous pharmacokinetic studies (Saano et al. 1983; unpublished) on various drugs (not antiemetic), no such adverse reactions occurred, although the test arrangements (volunteer age, blood sampling, fasting, standard meals) were similar.

Slow-release NIF tablets caused dizziness significantly less frequently (p < 0.01; Wilcoxon’s signed rank test for paired samples) than capsules. Other side effects were equally intense and equally frequent after both preparation forms.

The results suggest that gastrointestinal side effects of NIF may be more common and more intense than expected. These untoward effects may be of importance especially when NIF is used as an antihypertensive, where patients are younger and more active than NIF-treated patients suffering from angina pectoris.

Key words

  • Nifedipine
  • Nausea
  • Vomiting
  • Headache

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-642-71248-7_29
  • Chapter length: 2 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   119.00
Price excludes VAT (USA)
  • ISBN: 978-3-642-71248-7
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   159.00
Price excludes VAT (USA)

References

  • Terry RW (1982) Nifedipine therapy in angina pectoris. Evaluation of safety and side effects. Am Heart J 104: 681–689

    PubMed  CrossRef  CAS  Google Scholar 

  • Foster TS, Hamann SR, Richards VR, Bryant PJ, Graves DA, McAllister RG (1983) Nifedipine kinetics and bioavailability after single intravenous and oral doses in normal subjects. J Clin Pharmacol 23: 254–264

    Google Scholar 

  • Saano V, Tuomisto J, Airaksinen MM (1983) Paracetamol absorption from an effervescent and two vonventional tablets. Acta Pharm Fenn 92: 77–83

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 1986 Springer-Verlag

About this paper

Cite this paper

Saano, V., Komulainen, H. (1986). Nifedipine Induces Intense Nausea and Vomiting in Young, Healthy Volunteers. In: Chambers, C.M., Chambers, P.L., Tuomisto, J. (eds) Toxic Interfaces of Neurones, Smoke and Genes. Archives of Toxicology, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71248-7_29

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71248-7_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16589-7

  • Online ISBN: 978-3-642-71248-7

  • eBook Packages: Springer Book Archive