Detection of Cardiotoxic Hazards

  • G. Zbinden
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 9)


For the detection and quantitative assessment of cardiovascular toxicity, the morphological and biochemical studies used in routine toxicity tests must be supplemented with functional and metabolic measurements. Examples are given which show that the cardiotoxic effects of allylamine and emetine can be detected early by blood pressure and ECG monitoring. The same techniques are helpful in assessing potential drug interactions. For the hypoglycemic agent MTG measurement of mitochondrial function proved to be the most adequate method to demonstrate cardiotoxic hazard.

Key words

Cardiotoxicity Allylamine Emetine Amitriptyline 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • G. Zbinden
    • 1
  1. 1.Institute of ToxicologyETH and University of ZurichCH-SchwerzenbachSwitzerland

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