Tumor Markers: Their Role and Limit for Management of Pineal Tumor

  • N. Arita
  • Y. Ushio
  • T. Hayakawa
  • S. Bitoh
  • M. Kano
  • Y. Oku
  • S. Mori
  • H. Hasegawa
  • Y. Maeda
  • H. Mogami
Conference paper

Abstract

The 5 year survival rate of patients with pineal tumor has been reported to be between 25 and 79% in the literature (Abay et al. 1981). One of the reasons for this wide variation may be the different therapeutic regimens chosen by each neurosurgeon. The most important reason, however, might be the fact that the treated tumors in each series consisted of histologically different types. Pineal tumors include germ cell tumors, pineoblastomas, pineocytomas, gliomas, and other cystic tumors, and they show different responses to treatments. Recently, specific tumor markers such as alphafetoprotein (AFP) and human chorionic gonadotropin (HCG) were reported to be useful indicators for the management of intracranial germ cell tumors (Allen et al. 1979; Arita et al. 1980; Arita 1985). In this report, we discuss the rational treatment of tumors in the pineal region, especially the surgical indications and the role of tumor markers in the management of germ cell tumors.

Keywords

Cisplatinum Methotrexate Stein Hydrocephalus Cytosine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abay EO, Laws ER Jr, Grado Gl, Bruckman JE, Forbes GS, Gomez MR, Scott M (1981) Pineal tumors in children and adolescents. Treatment by CSF shunting and radiotherapy. J Neurosurg 55: 889–895PubMedCrossRefGoogle Scholar
  2. Allen JC, Nisselbaum J, Epstein F, Rosen G, Schwartz MK (1979) Alphafetoprotein and human chorionic gonadotropin determination in cerebrospinal fluid. An aid to the diagnosis and management of intracranial germ-cell tumors. J Neurosurg 51: 368–374PubMedCrossRefGoogle Scholar
  3. Arita N, Ushio Y, Hayakawa T, Watanabe M, Mori T, Mogami H (1980) Serum levels of alphafetoprotein, human chorionic gonadotropin and carcinoembryonic antigen in patients with primary intracranial germ cell tumor. Oncodev Biol Med 1: 235–240PubMedGoogle Scholar
  4. Arita N (1985) The role of tumor markers in the management of primary intracranial germ cell tumors. Neurosurgeons 4: 101–113 (in Japanese)Google Scholar
  5. Jamieson KG (1971) Excision of pineal tumors. J Neurosurg 35: 550–553PubMedCrossRefGoogle Scholar
  6. Jooma R, Kendall BE (1983) Diagnosis and management of pineal tumors. J Neurosurg 58: 654–665PubMedCrossRefGoogle Scholar
  7. Kobayashi S, Sugita K, Tanaka Y, Kyoshima K (1983) Infratentorial approach to the pineal region in the prone position: Concorde position. J Neurosurg 58: 141–143PubMedCrossRefGoogle Scholar
  8. Lazar ML, Clark K (1974) Direct surgical management of masses in the region of the vein of Galen. Surg Neurol 2: 17–21PubMedGoogle Scholar
  9. Reid WS, Clark WK (1978) Comparison of the infratentorial and transtentorial approaches to the pineal region. Neurosurgery 3: 1–8PubMedCrossRefGoogle Scholar
  10. Sano K (1983) Pineal region tumors: Problems in pathology and treatment. Clin Neurosurg 30: 59–91PubMedGoogle Scholar
  11. Stein BM (1971) The infratentorial supracerebellar approach to pineal lesions. J Neurosurg 35: 197–202PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • N. Arita
    • 1
  • Y. Ushio
    • 1
  • T. Hayakawa
    • 1
  • S. Bitoh
    • 1
  • M. Kano
    • 1
  • Y. Oku
    • 1
  • S. Mori
    • 1
  • H. Hasegawa
    • 1
  • Y. Maeda
    • 1
  • H. Mogami
    • 1
  1. 1.OsakaJapan

Personalised recommendations