Abstract
In order to decide whether beta-blockers or calcium antagonists are preferable as initial antihypertensive therapy, we investigated the efficacy of monotherapy with oxprenolol (160 mg once daily) and nitrendipine (20 mg once daily) in a single-blind randomized study. Only male civil servants with mild hypertension were included (\(\overline x \) = 43±6years of age; n=92). Clinical casual blood pressure (BP) was lowered equally in both groups, as was average BP at work, as assessed by ambulatory BP monitoring with Remler M2000 (123 ±12/81 ±14 vs. 129± 17/80 ± 10mmHg). This was done after casual BP had been within the normotensive range for 3 months. At equal levels of self-reported arousal and physical activity, systolic BP was lower in patients receiving oxprenolol. In the nitrendipine group, 24% discontinued therapy because of side effects, whereas only 12% receiving oxprenolol initially reported intolerable side effects. Patients on a regimen of oxprenolol reported less intense Type A characteristics in questionnaires administered after 3 months of therapy.
Keywords
- Calcium Antagonist
- Ambulatory Blood Pressure Monitoring
- Mental Arithmetic
- Cold Pressor Test
- Blood Pressure Reading
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Rüddel, H. et al. (1986). Biobehavioral Effects of Antihypertensive Monotherapy: Oxprenolol and Nitrendipine. In: Schmidt, T.H., Dembroski, T.M., Blümchen, G. (eds) Biological and Psychological Factors in Cardiovascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71234-0_37
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DOI: https://doi.org/10.1007/978-3-642-71234-0_37
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