Abstract
Hepatitis related to halothane has been found to follow about 1 in 35000 halothane anaesthesia [1]. One of the most important factors in unexplained hepatitis following halothane (UHFH) is repeated exposure to halothane within a short period, and the results of the investigation of a prospective series of patients undergoing radium implantation in Oxford in 1973–1974 appeared to confirm the association [2]. Subsequently, there has been extreme reluctance to repeat the use of halothane for anaesthesia within a few weeks (especially in middle-aged, obese women being treated for carcinoma of the cervix), despite other reports which show lack of adverse hepatic effects [3, 4].
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References
Stock GL, Strunin L (1985) Unexplained hepatitis following halothane. Anesthesiology 63:424– 439
Trowell J, Peto R, Smith AC (1975) Controlled trial of repeated halothane anaesthetics in patients with carcinoma of the uterine cervix treated with radium. Lancet 1: 821–831
Allen PJ, Downing JW (1977) A prospective study of hepatocellular function after repeated exposures to halothane or enflurane in women undergoing radium therapy for cervical cancer. Br J Anaesth 49: 1035–1039
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Blogg CE, Sear JW (1985) Isoflurane: Metabolism, hepatic function and toxicity. In: Bennetts FE (ed) Isoflurane. The current position. Proceedings of a symposium. Medical Education Servicesm Oxford, England, pp 29–33
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© 1986 Springer-Verlag Berlin Heidelberg
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Blogg, C.E., Sear, J.W., Dunnet, J., Brighouse, D. (1986). Toxicity of Repeat Isoflurane? A Preliminary Report. In: Lawin, P., Van Aken, H., Puchstein, C. (eds) Isoflurane. Anaesthesiology Intensive Care Medicine/Anaesthesiologie und Intensivmedizin, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71230-2_6
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DOI: https://doi.org/10.1007/978-3-642-71230-2_6
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