Isoflurane and Malignant Hyperthermia
Unexpected fever during or following anesthesia associated with death of the patient has been reported several times since the beginning of this century, but it was Denborough and Lovell  who in 1960 recognized the genetic nature of malignant hyperthermia (MH). The following years witnessed a blossoming of research into the diagnosis, treatment, genetic, and biochemical nature of MH. All potent inhalation anesthetics as well as succinylcholine were identified as possible triggering agents. By far the most crises have been reported with halothane because it has been available for 30 years, but there are also case reports of MH associated with isoflurane [3,9] and enflurane  anesthesia. In vitro contracture tests using halothane and caffeine are an essential part of our MH family screening program, which was started in 1976 and now contains the records of 230 investigated individuals. Following the introduction of isoflurane into clinical practice 2 years ago it seemed reasonable to compare the trigger effects of halothane and isoflurane in vitro.
KeywordsMuscle Tension Volatile Anesthetic Malignant Hyperther Malignant Hyperthermia Adenylate Kinase
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- 1.Britt BA (1982) Malignant hyperthermia: a review. In: Milton AS (ed) Pyretics and antipyretics. Springer, Berlin Heidelberg New York, pp 547–615 (Handbook of experimental pharmacology, vol 60 )Google Scholar
- 4.Brückner BJ (1985) Isoflurane: Ergebnisse klinischer Untersuchungen und wesentliche Indikationen der Anwendung. In: Bergmann H, Fitzal S, Steinbereithner K, Wiethoff EO, Zimpfer M (eds) Beiträge zur Anaesthesiologie und Intensivmedizin, vol 14: Isofluran - Standort und Perspektiven. Maudrich, Wien pp 147–173Google Scholar
- 7.European Malignant Hyperpyrexia Group (1984) A protocol for the investigation of malignant hyperpyrexia (MH) susceptibility. Br J Anaesth 56: 1267–1269Google Scholar
- 11.Leslie GC, MacLachlan DC (1976) Comments on isometric twitch tension responses of human muscle biopsy challenged in vitro with caffeine and halothane. Br J Anaesth 48: 1122Google Scholar