Abstract
An anaesthestic agent can be evaluated not only with regard to its influence on homeostasis as such but also in terms of its ability to protect the organism from surgical stress. Responses to surgical trauma are largely mediated through the autonomic nervous system and adrenal medulla and are, therefore, reflected by increases in heart rate, blood pressure, and concentrations of stress-associated substances in the circulation during and after surgery. Increases in Cortisol and catecholamines are considered to be reliable indicators of surgical trauma and manifestations of the physiological response to stress [21, 25]. It has also been suggested that beta-endorphins play a definite role in the biologic response to stress as well as in the endogenous mode of pain perception [12].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bedford RF, Marshall WK (1984) Cardiovascular response to endotracheal intubation during four anesthetic techniques. Acta Anaesth Scand 28: 563–566
Brismar B, Hedenstierna G, Lundh R, Tokics L (1982) Oxygen uptake, plasma catecholamines and cardiac output during neurolept-nitrous oxide and halothane anaesthesia. Acta Anaesth Scand 26: 541–549
Brown FF III, Owens WD, Felts JA, Spitznagel EL, Cryer PE (1982) Plasma epinephrine and norepinephrine levels during anesthesia: enflurane-N2O-O2 compared with fentanyl N2O-O2. Anesth Analg 61: 366–370
Cork RC, Hameroff SR, Weiss JL (1985) Effects of halothane and fentanyl anesthesia on plasma ß-endorphin immunoreactivity during cardiac surgery. Anesth Analg 64: 677–680
Cummings MF, Russell WJ, Frewin DB (1983) Effects of pancuronium and alcuronium on the changes in arterial pressure and plasma catecholamine concentrations during tracheal intubation. Br J Anaesth 55: 619–623
Derbyshire DR, Smith G (1984) Sympathoadrenal responses to anaesthesia and surgery. Br J Anaesth 56: 725–739
Derbyshire DR, Chmielewski A, Vater M, Achola K, Smith G (1983) Plasma catecholamine responses to tracheal intubation. Br J Anaesth 55: 855–860
Derbyshire DR, Hunt PCW, Achola K, Smith G (1984) Midazolam and thiopentone: catecholamine and arterial pressure responses to induction and endotracheal intubation. Br J Anaesth 56: 429 P
Dubois M, Pickar D, Cohen M, Gadde P, Macnamara TE, Bunney WE (1982) Effects of fentanyl on the response of plasma beta-endorphin immunoreactivity to surgery. Anesthesiology 57: 468–472
Fell D, Derbyshire DR, Maile CJD, Larsson IM, Ellis R, Achola KJ, Smith G (1985) Measurement of plasma catecholamine concentrations. An assessment of anxiety. Br J Anaesth 57: 770–774
Glisson SN, Balasaraswathi K (1981) Isoflurane sympathoadrenal responses in man compared to enflurane and halothane. Anesthesiology 55 (Suppl.): A296
Guillemin R, Vargo T, Rossier J, Minick S, Ling N, Rivier C, Vale W, Bloom F (1977) ß-endorphin and adrenocorticotropin are secreted concomitantly by the pituitary gland. Science 197: 1367–1369
Hamberger B, Järnberg PO (1983) Plasma catecholamines during surgical stress: differences between neurolept and enflurane anaesthesia. Acta Anaesth Scand 27: 307–310
Hjemdahl P, Daleskog M, Kohan T (1979) Determination of plasma catecholamines by high performance liquid chromatography with electrochemical detection: a comparison with a radioenzymatic method. Life Sci 25: 131–138
Höllt V, Müller OA, Fahlbusch R (1979) ß-endorphin in human plasma: basal and pathologically elevated levels. Life Sci 25: 37–44
Järnberg PO, Efendic S, Hamberger B (1982) Hormonal and metabolic changes during neurolept and isoflurane anaesthesia. Anesthesiology 57: A247
Johnson GA, Peuler J, Baker CA (1977) Plasma catecholamine concentrations in normal subjects. Curr Ther Res 21: 898–902
Joyce JT, Roizen MF, Gerson JI, Grobecker H, Eger EI II, Forbes AR (1982) Induction of anesthesia with halothane increases plasma norepinephrine concentrations. Anesthesiology 56: 286–290
Joyce JT, Roizen MF, Eger EI II (1983) Effect of thiopental induction on sympathetic activity. Anesthesiology 59: 19–22
Nigrovic C, Mc Cullough LS, Wajskol A, Levin JA, Martin JT (1983) Succinylcholine-induced increases in plasma catecholamine levels in humans. Anesth Analg 62: 627–632
Oyama T (1973) Endocrine responses to anesthestic agents. Br J Anaesth 45: 276–281
Parikh RK, Naismith Sewnauth D, Campbell BC, Reid JL (1982) Comparison of halothane and fentanyl supplementation to general anaesthesia on the stress response of patients undergoing upper abdominal surgery. Br J Anaesth 54: 23 I P
Rawlinson WAL, Loach AB, Benedict CR (1978) Changes in plasma concentration of adrenaline and noradrenaline in anaesthetized patients during sodium nitroprusside-induced hypotension. Br J Anaesth 50: 937–943
Reitan JA, Stengert KB, Wymore ML, Martucci RW (1978) Central vagal control of fentanyl induced bradycardia during halothane anaesthesia. Anesth Analg 57: 31–36
Selye H (1976) Stress in health and disease. Butterworths, London
Skovsted P, Price ML, Price HL (1970) the effects of shortacting barbiturates on arterial pressure, preganglionic sympathetic activity and barostatic reflexes. Anesthesiology 33: 10–18
Stoelting RK (1977) Circulatory changes during direct laryngoscopy and tracheal intubation: influence of duration of laryngoscopy with or without prior lidocaine. Anesthesiology 47: 381–384
Traynor C, Hall GM (1981) Endocrine and metabolic changes during surgery: anaesthetic implications. Br J Anaesth 53: 153–16029.
Weatherhill D, Spence AA (1984) Anaesthesia and disorders of the adrenal cortex. Br J Anaesth 56: 741–749
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Fitzal, S., Spiss, C., Schwarz, S., Weindlmayr-Göttel, M., Winkler, M. (1986). Plasma Levels of Stress Hormones Under Isoflurane Anaesthesia in Comparison to Other Anaesthetic Techniques. In: Lawin, P., Van Aken, H., Puchstein, C. (eds) Isoflurane. Anaesthesiology Intensive Care Medicine/Anaesthesiologie und Intensivmedizin, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71230-2_39
Download citation
DOI: https://doi.org/10.1007/978-3-642-71230-2_39
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16574-3
Online ISBN: 978-3-642-71230-2
eBook Packages: Springer Book Archive