Abstract
A large body of reports of animal experiments demonstrate that isoflurane is a coronary vasodilator which interferes with autoregulation. Its potency appears to be considerably greater than that of halothane or enflurane, but less than that of adenosine (Fig.1) [1–7].
Supported by grants from the Swedish National Foundation Against Heart and Lung Diseases and the Umeå University Research Foundation
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References
Tarnow J, Eberlein HJ, Oser G, Patschke D, Schneider E, Schweichel E, Wilde J (1977) Hämody- namik, Myokardkontraktilität, Ventrikelvolumina und Sauerstoffversorgung des Herzens unter verschiedenen Inhalationsanaesthetika. Anaesthetist 26: 220–230
Sybert PE, Hickey RF, Hoear PF, Verrier ED, Bainton CR (1983) Effects of volatile anesthetics on the regulation of coronary blood flow. Anesthesiology 59: A24 (abstract)
Lundeen G, Manohar M, Parks C (1983) Systemic distribution of blood flow in swine while awake and during 1.0 and 1.5 MAC isoflurane anesthesia with or without 50% nitrous oxide. Anesth Analg 62: 499–512
Gelman S, Fowler KC, Smith LR (1984) Regional blood flow during isoflurane and halothane anesthesia. Anesth Analg 63: 557–565
Vogel H, Günther H, Harrison DK, Kessler M, Peter K (1984) The influence of isoflurane and enflurane on tissue oxygenation and microcirculation of the dog myocardium. Anesthesiology 61: A5 (abstract)
Sill JC, Bove AA, Nugent M, Blaise G, Dewey JD, Grabau C (1985) Effects of isoflurane on proximal and distal coronary vasculature in intact dogs. Anesthesiology 63:All (abstract)
Buffington CW, Romson JL, Duttlinger NC (1985) Does isoflurane cause coronary steal? Anesthesiologie 63: A9 (abstract)
Reiz S, Bålfors E, Sørensen MB, Ariola Jr S, Friedman A, Truedson H (1983) Isoflurane - a powerful coronary vasodilator in patients with coronary artery disease. Anesthesiology 59: 91–97
Moffitt EA, Barker RA, Glenn JJ, Imrie DD, DelCampo C, Landymore R, Kinley CE, Murphy DA (1984) Myocardial metabolism and hemodynamic responses with isoflurane anesthesia for coronary artery surgery. Anesth Analg 63: 252 (abstract)
Harder DR, Belardinelli L, Sperelakis N, Rubio R, Berne RM (1979) Differential effects of adenosine and nitroglycerin on the action potentials of large and small arteries. Circ Res 44: 176–182
Becker LC (1976) Effects of nitroglycerin and dipyridamole on regional left ventricular blood flow during coronary artery occlusion. J Clin Invest 58: 1287–1296
Becker LC (1978) Conditions for vasodilator-induced coronary steal in experimental myocardial ischemia. Circulation 57: 1103–1110
Henry PD, Shuchleib R, Borda LJ, Roberts R, Williamson JR, Sobel BE (1978) Effects of nifedipine on myocardial perfusion and ischemic injury in dogs. Circ. Res 43: 372–380
Chiariello M, Gold HK, Leinbach RC, Davis MA, Maroko PR (1976) Deleterious effects of nitro- prusside in myocardial injury during acute myocardial infarction. Circulation 54: 766–773
Albro Pc, Gould KL, Westcott RJ, Hamilton GW, Ritchie JL, Williams DL (1978) Noninvasive assessment of coronary stenoses by myocardial imaging during pharmacologic coronary vasodilation. III. Clinical trial. Am J Cardiol 42: 751–760
Leppo JA, O’Brien J, Rothendler JA, Getchell JD, Lee VW (1984) Dipyridamole-thallium-201 scin-tigraphy in the prediction of future cardiac events after acute myocardial infarction. N Engl J Med 310: 1014–1018
Leppo J, Boucher CA, Okada RD, Newell JB, Strauss HW, Pohost GM (1982) Serial thallium-201 myocardial imaging after dipyridamole infusion: diagnostic utility in detecting coronary stenoses and relationship to regional wall motion. Circulation 66: 649–657
Boucher CA, Brewster DC, Darling RC, Okada RD, Strauss HW, Pohost GM (1985) Determination of cardiac risk by dipyridamole-thallium imaging before peripheral vascular surgery. N Engl J Med 312: 389–394
Reiz S, Östman M (1985) Regional coronary hemodynamics during isoflurane-nitrous oxide anesthesia in patients with ischemic heart disease. Anesth Analg 64: 570–576
Hess W, Arnold B, Schulte-Sasse U, Tarnow J (1983) Comparison of isoflurane and halothane when used to control intraoperative hypertension in patients undergoing coronary artery bypass surgery. Anesth Analg 62: 15–20
Tarnow J, Markschies-Hornung A, Schulte-Sasse U (1986) Isoflurane improves the tolerance to pacing-induced myocardial ischemia. Anesthesiology (to be published)
Reiz S, Häggmark S, Östman M (1976) Invasive analysis of non-invasive indicators of myocardial work and ischemia during anaesthesia soon after myocardial infarction. Acta Anaesthesiol Scand 25: 303–311
Moffitt EA, Sethna DH, Gray RJ, DeRobertis M, Matloff JM, Bussell JA (1984) Rate-pressure product correlates poorly with myocardial oxygen consumption during anaesthesia in coronary patients. Can Anaesth Soc J 31: 5–12
Gobel FL, Nordstrom LA, Nelson RR, Jorgensen CR, Wamg Y (1978) The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris. Circulation 57: 549–556
Larsen R, Hilfiker O, Merkel G, Sonntag H, Drobnik L (1985) Myocardial oxygen balance during enflurane and isoflurane anesthesia for coronary artery surgery. Anesthesiology 61: A4 (abstract)
Reiz S, Rydvall A, Häggmark S (1985) Coronary haemodynamic effects of surgery during enflurane-nitrous oxide anaesthesia in patients with ischaemic heart disease. Acta Anaesthesiol Scand 29: 106–112
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Reiz, S., Lowenstein, E. (1986). Isoflurane and Myocardial Ischemia. In: Lawin, P., Van Aken, H., Puchstein, C. (eds) Isoflurane. Anaesthesiology Intensive Care Medicine/Anaesthesiologie und Intensivmedizin, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71230-2_35
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DOI: https://doi.org/10.1007/978-3-642-71230-2_35
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