Abstract
To date, the pharmacological profile of volatile anesthetics is characterized by the decrease of cerebral oxygen and glucosis consumption by about 25% [7], combined with an increase of cerebral perfusion rate (rCBF) and intracranial pressure (ICP) because of reduced vascular tone. Halothane is associated with myocardial depression and enflurane with the irritation of the hippocampus and the nucleus amygdalae, with subsequent lowering of the seizure threshold [14, 21]. Finally, the extinction of cortical electrical activity (EEG) reflects toxic effects of these halogenated gases on the neuronal oxidative glucosis phosphorylation.
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Schoeppner, H. (1986). Influences of Isoflurane on the Electroencephalogram. In: Lawin, P., Van Aken, H., Puchstein, C. (eds) Isoflurane. Anaesthesiology Intensive Care Medicine/Anaesthesiologie und Intensivmedizin, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71230-2_22
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DOI: https://doi.org/10.1007/978-3-642-71230-2_22
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