Abstract
Muscle relaxants interact with a large range of other drugs and diseases and some of these interactions, such as the interaction with other muscle relaxants are intentionally employed. Commonly encountered interactions, such as the potentiation of pancuronium by enflurane, are not usually a problem, while the unexpected prolongation of the action of pancuronium by an antibiotic may be a cause for concern. This lecture will cover most of the drug-relaxant interactions and attempt to put them into perspective.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Katz RL (1971) Modification of the action of pancuronium by succinylcholine and halothane. Anesthesiolgy 35:602–606
Cullen DH (1971) The effect of pretreatment with nondepolarizing muscle relaxants on the neuro-muscular blocking action of succinylcholine. Anesthesiology 35:572–578
Foldes FF, Schwarz S, Ilias W, et al (1984) Rapid tracheal intubation with vecuronium: The priming principal. Anesthesiology 61:A294
Lebowitz PW, Ramsey FM, Savarese J J, et al (1980) Potentiation of neuromuscular blockade in man produced by combinations of pancuronium and metocurine or pancuronium and d-tubocurarine. Anesth Anaig (Cleve) 59:604–609
Miller RD (1975) Factors affecting the action of muscle relaxants. Muscle Relaxants. Edited by RL Katz. New York, American Elsevier Publishing Co, pp 163–191
Karis JH, Nastuk WL, Katz RL (1966) The action of tacrine on neuromuscular transmission: A comparison with hexafluorenium. Br J Anaesth 38:762–774
Ngai SH (1975) Action of general anesthetics in producing muscle relaxation; Interaction of anesthetics with relaxants. Muscle Relaxants. Edited by RL Katz. New York, Amerikcan Elsevier Publishing Co, pp 163–191
Hughes R, Payne JP (1979) Interaction of halothane with non-depolarizing neuromuscular blocking drugs in man. Br J Clin Pharmac 7:485–490
Miller RD, Rupp SM, Fisher DM, et al (1984) Clinical pharmacology of vecuronium and atracurium. Anesthesiology 61:444–453
Waud BE (1979) Decrease in dose requirement of d-tubocurarine by volatile anesthetics. Anesthesiology 51:298–302
Ali HH, Savarese JJ (1976) Monitoring of neuromuscular function. Anesthesiology 45:216–249
Edwards RP, Miller RD, Roizen MF, et al (1979) Cardiac responses to imipramine and pancuronium during anesthesia with halothane or enflurane. Anesthesiology 50:421–425
Geha DG, Rozelle BC, Raessler KL, et al (1977) Pancuronium bromide enhances atrioventricular conduction in halothane-anesthetized dogs. Anesthesiology 46:342–354
Amaki Y, Nagashima H, Radney PA, et al (1978) Ketamine interaction with neuromuscular blocking agents in the phrenic nerve-hemidiaphragm preparation of the rat. Anesth Anaig (Cleve) 57:238–243
Eisenberg M, Balsley S, Katz RL (1979) Effects of diazepam on succinylcholine-induced myalgia, potassium increase, creatitine Phosphokinase elevation, and relaxation. Anesth Anaig (Cleve) 58: 314–317
Grossman E, Jacobi AM (1974) Hemodynamic interaction between pancuronium and morphine. Anesthesiology 40:299–301
Durant NN, Lee C, Katz RL (1981) Cumulation of neomycin and its residual potentiation of tubocurarine in the cat. Br J Anaesth 53:571–576
Durant NN, Lambert JJ (1981) The action of polymyxin B at the frog neuromuscular junction. Br J Pharmac 72:41–47
Fogdall RP, Miller RD (1974) Prolongation of a pancuronium-induced neuromuscular blockade by polymyxin B. Anesthesiology 40:84–87
Hashimoto Y, Shima T, Matsukawa S, et al (1978) A possible hazard of prolonged neuromuscular blockade by amikacin. Anesthesiology 49:219–220
Jensen HA, Dalsgaard M (1972) Neuromuscular blocking effect of gentamicin as a possible cause of respiratory insufficiency. Ugeskr Laeg 134:1855–1856
Regan AG, Perumbetti PPV (1980) Pancuronium and gentamicin interaction in patients with renal failure. Anesth Anaig (Cleve) 59:393
Pittinger CB, Eryasa Y, Adamson R (1970) Antibiotic-induced paralysis. Anesth Anaig (Cleve) 49:487–501
Giala MM, Paradelis AG (1979) Two cases of prolonged respiratory depression due to interaction of pancuronium with Colistin and streptomycin. J antimicr Chemother 5:234–235
Waterman PM, Smith RB (1977) Tobramycin-curare interaction. Anesth Anaig (Cleve) 56:587–588
Booij LH DJ, Miller RD, Crul JF (1978) Neostigmine and 4-aminopyridine antagonism of lincomycin-pancuronium neuromuscular blockade in man. Anesth Anaig (Cleve) 57:316–321
Fogdall RP, Miller RD (1974) Prolongation of pancuronium-induced neuromuscular blockade by clindamycin. Anesthesiology 41:407–408
Poulton TJ, James FM, Lockridge O (1979) Prolonged apnea following trimethaphan and succinylcholine. Anesthesiology 50:54–56
Bowman WC (1980) Prejunctinal and postjunctional cholinoceptors at the neuromuscular junction. Anesth Analg (Cleve) 59:935–943
Matsuo S, Rado DBS, Chaudry I, et al (1978) Interaction of muscle relaxants and local anesthetics at the neuromuscular junction. Anesth Analg (Cleve) 57:580–587
Miller RD, Way WL (1971) Inhibition of succinylcholine-induced increased intragastric pressure by nondepolarizing muscle relaxants and lidocaine. Anesthesiology 34:185–188
Durant NN, Nguyen N, RL Katz (1984) Potentiation of neuromuscular blockade by verapamil. Anesthesiology 60:298–303
Zalman F, Perloff JK, Durant NN, et al (1983) Acute respiratory failure following intravenous verapamil in Duchenne’s muscular dystrophy. Am Heart J 105:510–511
Miller RD, Roderick LL (1978) Diuretic-induced hypokalaemic, pancuronium neuromuscular blockade and its antagonism by neostigmine. Br J Anaesth 50: 541–544
Miller RD, Sohn YJ, Matteo JS (1976) Enhancement of d-tubocurarine neuromuscular blockade by diuretics in man. Anesthesiology 45: 442–445
Azar I, Cottrell J, Gupta B, et al (1980) Furosemide recovery of evoked twitch response after pancuronium. Anesth Analg (Cleve) 59:55–57
Waziri R, Davenport R (1970) Lithium effects on neuromuscular transmission in manic patients. Comm Psychopharmac 3:121–127
Hill GE, Wong KC, Hodges MR (1976) Potentiation of succinylcholine neuromuscular blockage by lithium carbonate. Anesthesiology 44:439–443
Borden H, Clarke M, Katz H (1974) The use of pancuronium bromide in patients receiving lithium carbonate. Can Anaes Soc J 21:79–82
Whittaker M (1980) Plasma Cholinesterase variants and the anaesthetist. Anaesthesia 35:174–197
Glisson SN, El-Etr AA, Lim R (1979) Prolongation of pancuronium-induced neuromuscular blockade by intravenous infusion of nitro-glycerin. Anesthesiology 51:47–49
Durant NN, Briscoe JR, Katz RL (1984) The effects of acute and chronic hydrocortisone treatment on neuromuscular blockade in the anesthetized cat. Anesthesiology 61:144–150
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Durant, N.N., Katz, R.L. (1986). Interactions of Drugs and Disease with Muscle Relaxants. In: List, W.F., Schalk, H.V., Fitzal, S. (eds) Aktueller Stand der klinischen Anaesthesie. Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine, vol 190. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71229-6_25
Download citation
DOI: https://doi.org/10.1007/978-3-642-71229-6_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16573-6
Online ISBN: 978-3-642-71229-6
eBook Packages: Springer Book Archive