The Effect of Local Hyperthermia on the Tissue Oxygen Tension of Melanoma in the Hamster

  • B. Endrich
  • J. Voges
  • A. Lehmann
Conference paper


The cytotoxic effect of hyperthermia in malignant tumors varies with the heat distribution in the tumor and in the surrounding tissue. Therefore, nutritive tumor circulation and morphologic changes in the microvasculature after the temperature increase are important variables in reaching a complete destruction of tumor cells under in vivo conditions [1–4, 11]. Hyperthermia not only induces environmental changes in the interstitial space, but also affects the thermosensitivity and the development of thermotolerance [11]. Nevertheless, since devices for noninvasive temperature measurements have not yet become available for routine use in clinical practice, hyperthermia is still being induced without knowledge of the actual temperature in the tumor. Moreover, to date, theoretical calculations of the heat distribution within a tumor have not been acceptable as an approximation of the temperature variations. If, however, a detailed quantitative analysis of tissue oxygenation and microhemodynamics under local hyperthermia of malignant tumors became available, a theoretical basis could be provided for mathematical models.


Tissue Oxygenation Intravital Microscope Capillary Perfusion Tissue Oxygen Tension Intravascular Pressure 
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  1. 1.
    Dickson, J. A., S. K. Calderwood: Thermosensitivity of neoplastic tissues in vivo. In: F. K. Storm, G. K. Hall (eds.): Hyperthermia in Cancer Therapy. Medical Publishers, Boston (1983) pp 63–140Google Scholar
  2. 2.
    Eddy, H. A.: Alterations in tumor microvasculature during hyperthermia. Radiol. 137 (1980) 515–521Google Scholar
  3. 3.
    Emami, B., G. H. Nussbaum, N. Hahn, A. Dritschilo, F. Quimby: Histopathological study on the effects of hyperthermia on microvasculature. Int. J. Rad. One. Biol. Phys. 7 (1981) 343–348CrossRefGoogle Scholar
  4. 4.
    Endlich, B., B. W. Zweifach, H. S. Reinhold, M. Intaglietta: Quantitative studies of microcirculatory function in malignant tissue: Influence of temperature on microvascular hemodynamics during the early growth of the BA1112 rat sarcoma. Int. J. Rad. One. Biol. Phys. 5 (1979) 2021–2030CrossRefGoogle Scholar
  5. 5.
    Endlich, B., K. Asaishi, A. Götz, K. Meßmer: Technical Report — A new chamber technique for microvascular studies in unanesthetized hamsters. Res. Exp. Med. 177 (1980) 125–134CrossRefGoogle Scholar
  6. 6.
    Intaglietta, M., N. R. Silverman, W. R. Tompkins: Capillary flow velocity measurements in vivo and in situ by television method. Microvasc. Res. 10 (1975) 165–179PubMedCrossRefGoogle Scholar
  7. 7.
    Jain, R. K.: Bioheat transfer. Mathematical models of thermal systems. In: F. K. Storm, G. K. Hall (eds.): Hyperthermia in Cancer Therapy. Medical Publishers, Boston (1983) pp 9–46Google Scholar
  8. 8.
    Johnson, P.C.: The myogenic response. In: D. F. Bohr, A. P. Somlyo, H. V. Sparks (eds.): Hand-book of Physiology (Vol II, Sect). Amer. Physiol. Soc., Bethesda (1980) pp 409–442Google Scholar
  9. 9.
    Kessler, M., W. A. Grunewald: Possibilities of measuring oxygen pressure fields in tissue by multiwire platinum electrodes. Prog. Respir. Res. 3 (1969) 147–152Google Scholar
  10. 10.
    Lübbers, D. W.: Principle of construction and application of various platinum electrodes. Prog. Respir. Res. 3 (1969) 136–146Google Scholar
  11. 11.
    Vaupel, P., W. Müller-Klieser, J. Otte, R. Manz, F. Kallinowski: Blood flow, tissue oxygenation, and pH-distribution in malignant tumors upon localized hyperthermia — Basic pathophysiological aspects and the role of various thermal doses. Strahlenth. 159 (1983) 73–81Google Scholar

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© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • B. Endrich
  • J. Voges
  • A. Lehmann

There are no affiliations available

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