Comparative Hemodynamic Measurements Including Tissue PO2 Measurements on the Liver under Vasopressin and Triglycyllysine Vasopressin
In 1979, our attention was drawn to the vasopressin derivative triglycyllysine vasopressin (TGLVP), which seemed to be well suited for the treatment of acute hemorrhage from esophageal piles. The drug Glycylpressin (Ferring Pharmaceuticals, Kiel) was introduced as a vasopressin derivative which has a selective effect on the visceral system lasting for more than several hours and without the side effects of vasopressin. Arguments against vasopressin treatment of acute esophageal pile hemorrhage included, first, cardiotoxic side effects, and, secondly, negative effects on the liver parenchyma, which is already damaged as a result of diminished arterial and venous perfusion. Korsback , for instance, reported an approximately 40% reduction of the partial oxygen pressure in the liver under intravenous vasopressin infusion: 37 mm Hg before vasopressin infusion and 20.5 mm Hg afterwards.
KeywordsPartial Oxygen Pressure Liver Perfusion Acute Hemorrhage Flow Reduction Portal Venous Flow
Unable to display preview. Download preview PDF.
- 1.Kessler, M., D. W. Lübbers: Aufbau und Anwendungsmögliehkeiten verschiedener pO2Elektroden. Pflüg. Arch. 291 (1966) 82Google Scholar
- 2.Lübbers, D. W.: Die Bedeutung des lokalen Gewebesauerstoffpartialdrucks und des pO2-Histogramms für die Beurteilung der Sauerstoffversorgung eines Organs. Prakt. Anästh. 12 (1977) 184–193Google Scholar
- 3.Korsback, C.: Effect of Vasopressin on liver tissue pO2. Abstr. E.S.S.R., 15th Congress, Brüssel (1980)Google Scholar