The Effect of Muscle Exercise on Partial Oxygen Pressure in Dogs with Unilateral Chronically Ligated Leg Arteries

  • E. Böhm
  • K. Strein
  • G. Sponer
  • B. Müller-Beckmann
  • N. Würtz
Conference paper


One of the advantages of animal experimental models of diseases is that pathophysiological and pharmacological problems can be thoroughly investigated. For peripheral arterial occlusive disease, Sunder-Plassmann and Messmer developed a model on a dog with unilateral chronically ligated arteries of the leg [1, 2, 3]. The femoral artery is ligated at several places and all of its lateral branches, with the exception of the caudal femoral artery, are detached. This allows the stage of intermittent claudication to be simulated. In this phase, circulation in patients is still sufficient while they are resting, but during exercise the oxygen demand can no longer be adequately met. We therefore tried to discover differences in the reaction of the ligated and nonligated leg on muscle exercise with respect to the partial oxygen pressure as a measure of ischemia.


Partial Oxygen Pressure Lateral Branch Intermittent Claudication Peripheral Arterial Occlusive Disease Muscle Stimulation 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • E. Böhm
  • K. Strein
  • G. Sponer
  • B. Müller-Beckmann
  • N. Würtz

There are no affiliations available

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