Endotoxin-Induced Shock in the Pregnant Miniature Pig — Changes in Macro- and Microcirculation
In 1935, Apitz induced a generalized Shwartzman phenomenon (bilateral renal cortex necrosis, hemorrhagic diathesis, and shock) in rabbits by giving them two injections of endotoxin at a 24-h interval. He observed that one animal had already died after the first injection. This animal was pregnant . Based on this observation, numerous investigations were carried out which proved that animals in the last third of their gestation period generally require a lower dose of endotoxin to develop shock than nonpregnant control animals. The results all indicated that pregnancy has a predisposing effect for generalized Shwartzman phenomenon and for shock.
KeywordsCentral Venous Pressure Stroke Index Endotoxin Shock Shock Index Partial Carbon Dioxide Pressure
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