PO2 Distribution in Muscle and Renal Cortex of Rats with Chronic Liver Changes

  • R. Heinrich
  • S. Dette
  • N. Grein
  • M. Günderoth-Palmowski
  • W. Grauer
  • W. Fleckenstein
  • H. Schomerus
Conference paper


In man, cirrhosis with portosystemic shunting as a consequence of portal hypertension produces changes of systemic circulation, i.e. hyperdynamic circulatory syndrome, which are characterized by decreased peripheral vascular resistance as well as increased cardiac output, systolic ejection rate, and intrapulmonary venous admixture [4, 11, 12]. In addition, changes of renal perfusion, i.e., hyperperfusion of the medulla with diminished perfusion of the cortex, have been demonstrated. Functional renal failure as a consequence of decompensated cirrhosis (i.e., so-called hepatorenal syndrome) have been partially attributed to these intrarenal perfusion changes [8].


Renal Cortex Renal Perfusion Perfusion Change Portocaval Shunt Cortical Perfusion 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • R. Heinrich
  • S. Dette
  • N. Grein
  • M. Günderoth-Palmowski
  • W. Grauer
  • W. Fleckenstein
  • H. Schomerus

There are no affiliations available

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