The Effects of Bleeding and Hemodilution on Muscular PO2 in the Dog

  • W. Fleckenstein
  • T. Kersting
  • A. Schaffler
  • R. Heinrich
  • K. Reinhart
  • C. Weiss
Conference paper


Changes in the oxygen pressure in the skeletal muscle of the dog following experimentally induced changes in the circulating intravasal volume were studied with a newly developed method [4, 5, 6, 7] for fast registration of tissue PO2 histograms (based on 200 single local PO2 values obtained within 6 min). The objective of the experiments was to study the relationship between muscular PO2 on the one hand, and systemic O2 delivery, systemic O2 consumption, cardiac output, and systemic vascular resistance, on the other.


Cardiac Index Hemorrhagic Shock Mean Arterial Blood Pressure Hydroxyethyl Starch Systemic Oxygen 
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  1. 1.
    Äppelgren, L.: Perfusion and diffusion in shock. Acta Physiol. Scand. 378 (1972) 5–72Google Scholar
  2. 2.
    Cherniack, N. S., N. H. Edelmann, A. P. Fishman: O2 exchange across spleen during asphyxia. Am. J. Physiol. 219 (1970) 1585–1589PubMedGoogle Scholar
  3. 3.
    Ehrly, A.M., H.Landgraf, K.Saeger-Lorenz, S.Hasse: Verbesserung der Fließeigenschaften des Blutes nach Infusion von niedermolekularer Hydroxyäthylstärke (Expafusin) bei gesunden Probanden. Infusionstherapie 6 (1979) 331–336Google Scholar
  4. 4.
    Fleckenstein, W., C. Weiss: Evaluation of pO2-histograms obtained by hypodermic needle electrodes. In: W.Bleifeld, D.Harder, H.K.Leetz, M. Schaldach (eds.): Proceedings World Congress on Medical Physics and Biomedical Engineering, 7. 14, Kinzel, Göttingen, FRG (1982)Google Scholar
  5. 5.
    Fleckenstein, W.: Ein neues Gewebe-pO2-Meßverfahren zum Nachweis von Mikrozirkulationsstörungen. Focus MHL 1 (1984) 74–84Google Scholar
  6. 6.
    Fleckenstein, W., C. Weiss: A comparison of pO2-histograms from rabbit hindlimb muscles obtained by simultaneous measurements with hypodermic needle electrodes and with surface electrodes. Adv. Exp. Med. Biol. 169 (1984) 447–455PubMedGoogle Scholar
  7. 7.
    Fleckenstein, W., R. Heinrich, T. Kersting, H. Schomerus, C. Weiss: A new method for the bed-side recording of tissue pO2-histograms. Verh. Dtsch. Ges. Inn. Med. 90 (1984) 439–443Google Scholar
  8. 8.
    Grünewald, W., W. Sowa: Capillary structures and O2 supply to tissue. Rev. Physiol. Biochem. Pharmacol. 77 (1977) 149–209PubMedCrossRefGoogle Scholar
  9. 9.
    Honig, C. R., J. L. Frierson, C. N. Nelson: O2 transport and VO2 in resting muscle: significance for tissue-capillary exchange. Am. J. Physiol. 220 (1971) 357–363PubMedGoogle Scholar
  10. 10.
    Pappenheimer, J. R.: Blood flow, arterial oxygen saturation, and oxygen consumption in the isolated perfused hindlimb of the dog. J. Physiol. 99 (1941) 283–303PubMedGoogle Scholar
  11. 11.
    Sinagowitz, E., H. Rahmer, R. Rink, L. Görnandt, M. Kessler: Local oxygen supply in intra-abdominal organs and in skeletal muscle during hemorrhagic shock. Adv. Exp. Med. Biol. 37 A (1973)505–511Google Scholar
  12. 12.
    Stainsby, W. N., A. B. Otis: Blood flow, blood oxygen tension, oxygen uptake, and oxygen transport in skeletal muscle. Am. J. Physiol. 206 (1964) 858–866PubMedGoogle Scholar
  13. 13.
    Stainsby, W. N., C. R. Lambert: Determinants of oxygen uptake in skeletal muscle. Exerc. Sport Sci. Rev. 7 (1979) 125–151PubMedCrossRefGoogle Scholar
  14. 14.
    Whalen, W. J., D. Burek, C. Thuning, B. E. Kanoy, W. N. Duran: Tissue pO2, VO2, venous pO2 and perfusion pressure in resting dog gracilis muscle perfused at constant flow. Adv. Exp. Med. Biol. 75 (1976) 639–655PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • W. Fleckenstein
  • T. Kersting
  • A. Schaffler
  • R. Heinrich
  • K. Reinhart
  • C. Weiss

There are no affiliations available

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