Transcutaneous PO2 and PCO2 During Sleep in Patients with Chronic Obstructive Lung Disease Under Different Modes of Therapy
Patients suffering from chronic obstructive lung disease (COLD) frequently develop hypoxemia, i. e., oxygen desaturation, during sleep. This is caused by ventilation/perfusion inhomogeneity  or by diminished ventilation with a reduction in the tidal volume or the respiratory rate or apneic episodes (Fig. 1). It can be treated by raising the inspiratory oxygen concentration by administering 100% oxygen through a nasal prong . Another possibility is stimulating the respiratory center with centrally acting respiratory analeptics. We now have a drug at our disposal which stimulates the peripheral chemoreceptors and, particularly in the case of hypoxia, increases ventilatory drive.
KeywordsOxygen Desaturation Chronic Obstructive Lung Disease Inspiratory Oxygen Concentration Ventricular Ectopic Beat Peripheral Chemoreceptor
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