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Changes in Muscle Tissue PO2 Histograms of Patients with Arterial Occlusive Disease Following the Intravenous Injection of Calcium Dobesilate

  • A. M. Ehrly
  • H. Landgraf
Conference paper

Abstract

Dexium or Doxium (generic name calcium dobesilate; chemically calcium 2,5-dihydroxy benzenesulfonate) is a vasoactive compound, which until now has been used particularly in the treatment of diabetic retinopathy and venous diseases [1, 2, 3]. The sealing effect the drug is assumed to have on the capillaries also results in a reduction in capillary permeability in diabetics [4]. After there were indications of effectiveness in chronic arterial occlusive disease, Mörl and coworkers found a statistically significant increase in the walking performance in patients with intermittent claudication after treatment with Dexium [5].

Keywords

Diabetic Retinopathy Intermittent Claudication Arterial Occlusive Disease Calcium Dobesilate Vasoactive Compound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Sevin, R., J.F.Cuendet: Calcium dobesilate in diabetic retinopathy. Ophthalmologica 159 (1969) pp 126–135, et Mémoires de la Société Française d’Ophthalmologie 82 (1969) pp 170–179PubMedCrossRefGoogle Scholar
  2. 2.
    Berson, I.: A propos d’un nouveau veinotrope de synthèse. Praxis 37 (1970) pp 1305–1306Google Scholar
  3. 3.
    Sevin, R.: Treatments for diabetic retinopathy. Adv. Ophthalmol. 24 (1971) pp 315–374PubMedGoogle Scholar
  4. 4.
    Beyer, J., K.O. Meißner, J. Happ und U.Cordes: Wirkung von Calciumdobesilat auf die Permeation von Plasmaproteinen beim Diabetiker. Dt. Med. Wschr. 105 (1980) S. 1604–1608CrossRefGoogle Scholar
  5. 5.
    Mörl, H., H.Hacker und H.C.Bierewitz: Behandlung arterieller Durchblutungsstörungen mit Dexium® 500. Therapiewoche 34 (1984) S. 2009–2014Google Scholar
  6. 6.
    Lübbers, D.W.: Grundlagen und Bedeutung der lokalen Sauerstoffdruckmessung und des pO2-Histogramms für die Beurteilung der Sauerstoffversorgung der Organe. In: A. M.Ehrly (Hrsg.): Messung des Gewebesauerstoffdrucks bei Patienten. Witzstrock-Verlag, Baden-Baden (1981)Google Scholar
  7. 7.
    Ehrly, A.M., H.-J. Köhler, W. Schroeder, R. Müller: Sauerstoffdruckwerte im ischämischen Muskelgewebe von Patienten mit chronischen peripheren arteriellen Verschlußkrankheiten. Klin. Wschr. 53 (1975) S. 687PubMedCrossRefGoogle Scholar
  8. 8.
    Ehrly, A. M.: New pathophysiological concept of ischemic disease: Microcirculatory Blood Maldistribution (MBM). Bibl. Anat. 20 (1980) p 456Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • A. M. Ehrly
  • H. Landgraf

There are no affiliations available

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