Changes in Muscle Tissue PO2 Histograms of Patients with Arterial Occlusive Disease Following the Intravenous Injection of Calcium Dobesilate

  • A. M. Ehrly
  • H. Landgraf
Conference paper


Dexium or Doxium (generic name calcium dobesilate; chemically calcium 2,5-dihydroxy benzenesulfonate) is a vasoactive compound, which until now has been used particularly in the treatment of diabetic retinopathy and venous diseases [1, 2, 3]. The sealing effect the drug is assumed to have on the capillaries also results in a reduction in capillary permeability in diabetics [4]. After there were indications of effectiveness in chronic arterial occlusive disease, Mörl and coworkers found a statistically significant increase in the walking performance in patients with intermittent claudication after treatment with Dexium [5].


Diabetic Retinopathy Intermittent Claudication Arterial Occlusive Disease Calcium Dobesilate Vasoactive Compound 
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  1. 1.
    Sevin, R., J.F.Cuendet: Calcium dobesilate in diabetic retinopathy. Ophthalmologica 159 (1969) pp 126–135, et Mémoires de la Société Française d’Ophthalmologie 82 (1969) pp 170–179PubMedCrossRefGoogle Scholar
  2. 2.
    Berson, I.: A propos d’un nouveau veinotrope de synthèse. Praxis 37 (1970) pp 1305–1306Google Scholar
  3. 3.
    Sevin, R.: Treatments for diabetic retinopathy. Adv. Ophthalmol. 24 (1971) pp 315–374PubMedGoogle Scholar
  4. 4.
    Beyer, J., K.O. Meißner, J. Happ und U.Cordes: Wirkung von Calciumdobesilat auf die Permeation von Plasmaproteinen beim Diabetiker. Dt. Med. Wschr. 105 (1980) S. 1604–1608CrossRefGoogle Scholar
  5. 5.
    Mörl, H., H.Hacker und H.C.Bierewitz: Behandlung arterieller Durchblutungsstörungen mit Dexium® 500. Therapiewoche 34 (1984) S. 2009–2014Google Scholar
  6. 6.
    Lübbers, D.W.: Grundlagen und Bedeutung der lokalen Sauerstoffdruckmessung und des pO2-Histogramms für die Beurteilung der Sauerstoffversorgung der Organe. In: A. M.Ehrly (Hrsg.): Messung des Gewebesauerstoffdrucks bei Patienten. Witzstrock-Verlag, Baden-Baden (1981)Google Scholar
  7. 7.
    Ehrly, A.M., H.-J. Köhler, W. Schroeder, R. Müller: Sauerstoffdruckwerte im ischämischen Muskelgewebe von Patienten mit chronischen peripheren arteriellen Verschlußkrankheiten. Klin. Wschr. 53 (1975) S. 687PubMedCrossRefGoogle Scholar
  8. 8.
    Ehrly, A. M.: New pathophysiological concept of ischemic disease: Microcirculatory Blood Maldistribution (MBM). Bibl. Anat. 20 (1980) p 456Google Scholar

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© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • A. M. Ehrly
  • H. Landgraf

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