Biphenotypic Leukemia in Childhood: Presentation of Five Cases

  • A. Reifenhäuser
  • H. Jürgens
  • D. Schwamborn
  • A. Schmitt-Gräff
  • U. Göbel
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 30)

Abstract

Biphenotypic leukemias are characterized by both a lymphoid and a myeloid differentiation. They represent a heterogeneous subgroup of leukemias and include the following types:
  1. 1.

    Sequential manifestation: Leukemias with a conversion of the leukemic phenotype on relapse (“lineage switch”) [1–4]

     
  2. 2.

    Simultaneous manifestation:

     
  3. a)

    Leukemias with lymphoid and myeloid determinants present on the same cell (“lineage infidelity”) [5, 6]

     
  4. b)

    Leukemias with different cell lines present at the same time [7–10]

     

Keywords

Peroxi Leukemia Anemia Methotrexate Hull 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • A. Reifenhäuser
    • 1
  • H. Jürgens
    • 1
  • D. Schwamborn
    • 1
  • A. Schmitt-Gräff
    • 2
  • U. Göbel
    • 1
  1. 1.Children’s Hospital, Department of Pediatric Hematology and OncologyUniversity of DüsseldorfGermany
  2. 2.Insitute of PathologyUniversity of DüsseldorfDüsseldorfFederal Republic of Germany

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